{"id":"W2797584152","doi":"10.1056/nejmoa1801445","title":"Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":2261,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Frederick National Laboratory for Cancer Research; Leidos; Medical Research Council; Center for Strategic Scientific Initiatives, National Cancer Institute","keywords":"Biology; Germinal center; Diffuse large B-cell lymphoma; Lymphoma; Cell of origin; Gene expression profiling; Genetics; Gene; Pathogenesis; B cell; Cancer research; Gene expression; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704999,0.0002681043,0.0001487426,0.0007402851,0.000117958,0.000374488,0.0001895854,0.0002649887,0.0003401201],"category_scores_gemma":[0.0002376602,0.0001261266,0.000109767,0.0004938866,0.0004435099,0.0002002484,0.0001997524,0.0002009112,0.0001493876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005642152,"about_ca_system_score_gemma":0.0002186267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011516,"about_ca_topic_score_gemma":0.0008261171,"domain_scores_codex":[0.9999132,0.00002423591,0.000009034783,0.00002203277,0.00002060957,0.00001078486],"domain_scores_gemma":[0.9999138,0.00001726861,0.0000437777,0.000005438476,0.000008736272,0.00001097109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006176661,0.0001187191,0.5872307,0.0004982462,0.0002153676,0.009163708,0.0005322305,0.004905612,0.3094268,0.008306658,0.001146055,0.07783804],"study_design_scores_gemma":[0.0001393743,0.0003504305,0.8446537,0.0001519854,0.000308077,0.07230121,0.0006780325,0.009082098,0.03891744,0.01248672,0.02088546,0.00004549581],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9827604,0.0121565,0.002868652,0.0003337234,0.000006598566,0.00002224785,0.0001571495,0.00008647193,0.001608141],"genre_scores_gemma":[0.9937442,0.004417084,0.001301987,0.00007423014,0.00001295236,0.00001105834,0.00016356,0.000007885154,0.0002671308],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001011516,"threshold_uncertainty_score":0.004093707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415320434594938,"score_gpt":0.2627955426369702,"score_spread":0.2486423382910209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}