{"id":"W2797665682","doi":"10.1128/aac.00202-18","title":"Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Aminoglycoside; Enzyme; Binding site; Chemistry; Biochemistry; Biology; Stereochemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000741938,0.0001556092,0.0001673504,0.00005775618,0.00008465026,0.00002388214,0.0001764554,0.0001279641,0.00006225237],"category_scores_gemma":[0.00002899436,0.0001388038,0.00007017766,0.0001306194,0.0002189568,0.000003072112,0.0001393262,0.00006295335,0.00002705279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000597073,"about_ca_system_score_gemma":0.0000218325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003612394,"about_ca_topic_score_gemma":0.00001006318,"domain_scores_codex":[0.9990377,0.00002226827,0.0001730501,0.0003612765,0.0001110109,0.0002946248],"domain_scores_gemma":[0.9995366,0.000005487055,0.00004856485,0.0001834725,0.00008895471,0.0001368581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002057667,0.0001065771,0.004025127,0.00003156697,0.00005046984,0.000002780284,0.00004718331,3.916505e-7,0.9740343,0.00001450864,0.01746801,0.00401332],"study_design_scores_gemma":[0.000636899,0.0004068137,0.007509829,0.00004167319,0.000008825959,0.000009556886,0.000009985351,0.00001073859,0.9639117,0.000006261445,0.02727916,0.0001685822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979111,0.00001743102,0.0007749097,0.0005421859,0.00006828578,0.0001806804,0.00002979077,0.000007276723,0.0004683718],"genre_scores_gemma":[0.994971,0.0001828663,0.0009302351,0.00311404,0.000190289,0.000001553427,0.00003017989,0.00002287876,0.0005569016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012263,"threshold_uncertainty_score":0.5660257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206688175270709,"score_gpt":0.2871549125805914,"score_spread":0.2750880308278844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}