{"id":"W2797665682","doi":"10.1128/aac.00202-18","title":"Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Aminoglycoside; Enzyme; Binding site; Chemistry; Biochemistry; Biology; Stereochemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122551,0.000292917,0.0004072523,0.0001616173,0.0001566117,0.0007329712,0.0003814083,0.0003120099,0.001119657],"category_scores_gemma":[0.0004649047,0.0002762258,0.0002788834,0.0001325256,0.0002344457,0.0002546534,0.0003502569,0.0004522783,0.0008149368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458795,"about_ca_system_score_gemma":0.0001971732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007961842,"about_ca_topic_score_gemma":0.0009325139,"domain_scores_codex":[0.9997784,0.00003656135,0.00001748701,0.00005627487,0.00006575836,0.00004541238],"domain_scores_gemma":[0.9997907,0.0000378198,0.00005267873,0.00003270329,0.00003343081,0.00005275716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005820646,0.00001004977,0.0007687827,0.00002122877,0.000009168588,0.00007717077,0.00002238929,0.0002897377,0.9976019,0.00009520425,0.0000323049,0.001013944],"study_design_scores_gemma":[0.00002133875,0.0002642762,0.03243355,0.00001367694,0.00003341244,0.001081918,0.0001397418,0.01268681,0.9497247,0.0002064675,0.003354094,0.00004004235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960487,0.0003497913,0.001579725,0.00003714242,0.000009400143,0.00001031912,0.00006154088,0.00006554204,0.001837768],"genre_scores_gemma":[0.9979311,0.0001333931,0.0009096764,0.00002451424,0.000003394766,0.000007229097,0.0001223666,0.00002457693,0.0008437296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119657,"threshold_uncertainty_score":0.003745556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01206688175270709,"score_gpt":0.2871549125805914,"score_spread":0.2750880308278844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}