{"id":"W2797679714","doi":"10.1016/j.ymthe.2018.04.009","title":"HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Simon Fraser University; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health","keywords":"Epitope; Immunology; HIV Antigens; Human leukocyte antigen; Virology; Antigen; Adoptive cell transfer; T cell; Biology; Immune system; Stem cell; Immunity; Medicine; Virus; Viral disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001288402,0.0002543873,0.0003193497,0.0001198715,0.0001262861,0.00004313128,0.0002191553,0.0002268288,0.001413492],"category_scores_gemma":[0.000008086121,0.0002149012,0.00007216015,0.000147512,0.0003048556,0.00005438864,0.00006447724,0.0002491674,0.003526076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004458558,"about_ca_system_score_gemma":0.0000409691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002752795,"about_ca_topic_score_gemma":0.00001949821,"domain_scores_codex":[0.9981909,0.0004661776,0.0002328278,0.0005278965,0.00005862347,0.0005235352],"domain_scores_gemma":[0.9992744,0.0001284289,0.00005413491,0.0003998523,0.00007950675,0.00006368067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009951987,0.0002132418,0.0003817613,0.00000181295,0.0002341004,0.0001766588,0.0006130654,0.000001284577,0.9681008,0.000004395407,0.006421774,0.02285586],"study_design_scores_gemma":[0.003897206,0.0002154958,0.0009239716,0.00001255973,0.000008109701,0.000007204092,0.00004997681,0.000006743363,0.8983703,0.00009796815,0.09621253,0.0001979773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837434,0.01372131,0.0003910188,0.0003444509,0.0003215097,0.0004462354,0.0005052843,0.00004300556,0.0004838049],"genre_scores_gemma":[0.9935613,0.003054914,0.0006764689,0.0004439355,0.00005021482,0.00005322424,0.0008708987,0.00003870944,0.001250344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08979075,"threshold_uncertainty_score":0.9994994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246611245204484,"score_gpt":0.2322979069536436,"score_spread":0.2198317945015987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}