{"id":"W2797709183","doi":"10.1002/mds.27360","title":"Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations","year":2018,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":362,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"","keywords":"Disease; Parkinson's disease; Dysfunctional family; Neuroscience; Intervention (counseling); Medicine; Bioinformatics; Mechanism (biology); Intensive care medicine; Psychology; Biology; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001746525,0.0006667265,0.001061344,0.0003593188,0.0001416064,0.00005205442,0.0001028727,0.0001583904,0.00009844317],"category_scores_gemma":[0.00004240034,0.0005616956,0.0003540025,0.0001766144,0.0001070299,0.0001082109,0.00008969319,0.0002750811,0.00004102444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003123423,"about_ca_system_score_gemma":0.0005089093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001009334,"about_ca_topic_score_gemma":0.00006222321,"domain_scores_codex":[0.997282,0.0001772245,0.0005683199,0.001104306,0.0004317158,0.0004364852],"domain_scores_gemma":[0.9981768,0.00004719794,0.0002596824,0.0007586247,0.00003763059,0.0007201111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005690886,0.001541553,0.0002679417,0.01248325,0.0002390571,0.00004460008,0.00008843253,4.467521e-7,9.608681e-9,0.007436004,0.001126692,0.9767151],"study_design_scores_gemma":[0.001200946,0.00006316807,0.00914575,0.003896557,0.001818369,5.004871e-7,0.000079744,0.0001010463,3.16195e-8,0.01415568,0.9690838,0.0004543934],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004459377,0.9934525,0.00002714854,0.002072373,0.0003356531,0.003188719,0.0003566359,0.00007323805,0.0004490691],"genre_scores_gemma":[0.0007180456,0.9946315,0.0001167784,0.0002368333,0.0003823086,0.002088626,0.001654896,0.00008533197,0.00008568619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9762607,"threshold_uncertainty_score":0.9996834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1163043361521717,"score_gpt":0.327486974901231,"score_spread":0.2111826387490593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}