{"id":"W2797764507","doi":"10.1007/s40291-018-0323-2","title":"A Discrete Event Simulation Model to Assess the Economic Value of a Hypothetical Pharmacogenomics Test for Statin-Induced Myopathy in Patients Initiating a Statin in Secondary Cardiovascular Prevention","year":2018,"lang":"en","type":"article","venue":"Molecular Diagnosis & Therapy","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Statin; Medicine; Rhabdomyolysis; Myopathy; Pharmacogenomics; Dyslipidemia; Internal medicine; Physical therapy; Intensive care medicine; Pharmacology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002871359,0.00133499,0.001502869,0.00144967,0.000688952,0.001650092,0.002045815,0.00322624,0.01203675],"category_scores_gemma":[0.01173741,0.0007180869,0.001685787,0.0009946001,0.001100223,0.0009737822,0.001185621,0.002540352,0.0004625462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004088654,"about_ca_system_score_gemma":0.003526782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05830134,"about_ca_topic_score_gemma":0.024987,"domain_scores_codex":[0.9987446,0.0007883427,0.00003622373,0.0001263512,0.00008531624,0.0002191413],"domain_scores_gemma":[0.985189,0.01258413,0.0006992574,0.0001881027,0.0007859566,0.0005535808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001338551,0.00004927452,0.001400136,0.00002190514,0.0000362563,0.00005657094,0.00001676393,0.9941112,0.00004974579,0.003265475,0.0002737297,0.0005851012],"study_design_scores_gemma":[0.00008362275,0.00007308445,0.0003449786,0.00001125454,0.00003225586,0.00001570903,0.00002758853,0.9975516,0.00003581516,0.001536748,0.000277288,0.00001002394],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7666624,0.001386361,0.1792372,0.005792587,0.0003288502,0.001033221,0.007858468,0.0003550459,0.03734588],"genre_scores_gemma":[0.9792126,0.0003383553,0.01138183,0.0002800461,0.00003523985,0.0005643963,0.001100047,0.00002128207,0.007066199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05830134,"threshold_uncertainty_score":0.1159239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04719126154893497,"score_gpt":0.3443562071018642,"score_spread":0.2971649455529292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}