{"id":"W2797874870","doi":"10.1002/acn3.559","title":"Poly(GP), neurofilament and grey matter deficits in <i>C9orf72</i> expansion carriers","year":2018,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; Instituto de Salud Carlos III; Medical Research Council; Alzheimer Nederland; Stichting Dioraphte; University College London Hospitals NHS Foundation Trust; Medicinska Forskningsrådet; Hjärnfonden; Alzheimer Society; Alzheimer's Society; Ministero della Salute; Stockholms Läns Landsting; Alzheimer’s Research UK; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Karolinska Institutet; ZonMw; Wolfson Foundation; Brain Research Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ALS Association; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Target ALS; Swedish Brain Power; Muscular Dystrophy Association; National Institutes of Health; Association for Frontotemporal Degeneration","keywords":"C9orf72; Grey matter; Frontotemporal dementia; Neurodegeneration; Medicine; Atrophy; Internal medicine; Amyotrophic lateral sclerosis; Pathology; Dementia; Disease; White matter; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254995,0.0007301644,0.0003247276,0.0007725235,0.0003401228,0.0003142459,0.0001531128,0.000519462,0.001916729],"category_scores_gemma":[0.0008642495,0.0001709447,0.0001894208,0.0002910927,0.0003719896,0.0002500151,0.0002236267,0.0002377939,0.0002063701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682422,"about_ca_system_score_gemma":0.0001123227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003432209,"about_ca_topic_score_gemma":0.002790578,"domain_scores_codex":[0.999912,0.00001252315,0.00001190742,0.00003262066,0.00001315439,0.00001781321],"domain_scores_gemma":[0.9996188,0.00008300448,0.0001729065,0.00001875675,0.00003274519,0.00007370844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003639826,0.0002216266,0.9015348,0.00004395636,0.000139797,0.003587593,0.0005002039,0.0001327965,0.08383792,0.0000743341,0.0002021289,0.006085017],"study_design_scores_gemma":[0.00002299354,0.0004678678,0.9952115,0.000007622153,0.00004970272,0.002203565,0.0001509291,0.0002535824,0.001496792,0.00004171096,0.0000874851,0.000006323303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998146,0.00002902218,0.00003220668,0.000005684958,0.000001190428,0.000002628922,0.00003735264,0.000001860917,0.00007539347],"genre_scores_gemma":[0.9996837,0.00002094403,0.00009410235,0.0000110067,0.000003338105,0.000003904048,0.00006904638,0.000002205263,0.0001117633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003432209,"threshold_uncertainty_score":0.006824493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281517640116678,"score_gpt":0.416655940710716,"score_spread":0.2885041766990482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}