{"id":"W2797874870","doi":"10.1002/acn3.559","title":"Poly(GP), neurofilament and grey matter deficits in <i>C9orf72</i> expansion carriers","year":2018,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Institute of Neurological Disorders and Stroke; Instituto de Salud Carlos III; Medical Research Council; Alzheimer Nederland; Stichting Dioraphte; University College London Hospitals NHS Foundation Trust; Medicinska Forskningsrådet; Hjärnfonden; Alzheimer Society; Alzheimer's Society; Ministero della Salute; Stockholms Läns Landsting; Alzheimer’s Research UK; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Karolinska Institutet; ZonMw; Wolfson Foundation; Brain Research Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ALS Association; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Target ALS; Swedish Brain Power; Muscular Dystrophy Association; National Institutes of Health; Association for Frontotemporal Degeneration","keywords":"C9orf72; Grey matter; Frontotemporal dementia; Neurodegeneration; Medicine; Atrophy; Internal medicine; Amyotrophic lateral sclerosis; Pathology; Dementia; Disease; White matter; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004087919,0.0001072825,0.0003822654,0.00009049298,0.00003708955,0.000005938846,0.00005211434,0.0001634469,0.0001764724],"category_scores_gemma":[0.0001084934,0.00008435677,0.00007176412,0.0001041876,0.0007021856,0.00006728825,0.00003565005,0.0003136997,0.00001558136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":2.284942e-7,"about_ca_system_score_gemma":0.00004986894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006568723,"about_ca_topic_score_gemma":0.00003395797,"domain_scores_codex":[0.9983937,0.0001915557,0.00060491,0.000340924,0.0002311436,0.0002377482],"domain_scores_gemma":[0.9990978,0.0004012564,0.00006751833,0.0001254796,0.000123887,0.0001840393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002114369,0.0001217889,0.983003,0.00003001335,0.00002099078,0.00002577552,0.00007643118,9.691805e-7,0.0006906867,0.0003007964,0.0003272417,0.01328794],"study_design_scores_gemma":[0.001574235,0.001273855,0.9930966,0.00002194596,0.00001177711,0.00003319492,0.000001980434,0.0003126836,0.0002155053,0.001617892,0.001778325,0.00006198415],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318981,0.0003914353,0.00001831132,0.06689195,0.00008406502,0.0001678557,0.0000099941,0.000007101357,0.0005311607],"genre_scores_gemma":[0.9847713,0.0005537232,0.0001061264,0.01434316,0.0001539632,0.000004717332,0.0000079785,0.00001110652,0.00004794117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05287316,"threshold_uncertainty_score":0.3439969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281517640116678,"score_gpt":0.416655940710716,"score_spread":0.2885041766990482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}