{"id":"W2797967938","doi":"10.1038/s41577-018-0007-5","title":"Understanding the drivers of MHC restriction of T cell receptors","year":2018,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":276,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council","keywords":"T-cell receptor; Major histocompatibility complex; Biology; MHC restriction; T cell; MHC class I; Computational biology; Germline; Genetics; Cell biology; Antigen; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0009228211,0.0005423372,0.002506465,0.0005187042,0.0002206057,0.000008187933,0.0007578198,0.002701202,0.00140075],"category_scores_gemma":[0.0004047026,0.0003398438,0.00120877,0.0008065972,0.0007504172,0.0001017364,0.0001786018,0.002809935,0.0008337756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003636234,"about_ca_system_score_gemma":0.0002053399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002049212,"about_ca_topic_score_gemma":0.000003705615,"domain_scores_codex":[0.9954744,0.001896736,0.001683393,0.000490043,0.00006971418,0.0003857029],"domain_scores_gemma":[0.9954825,0.0005895322,0.002756395,0.0009603747,0.0001982816,0.00001291991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003338337,0.0005302194,0.00001029322,0.02249798,0.004485852,0.000002715463,0.0007199317,4.077817e-7,0.009565941,0.00812692,0.4243873,0.5293386],"study_design_scores_gemma":[0.0003067766,0.0003411361,0.000002009168,0.00559166,0.001060734,0.00007679716,0.0001971388,7.626515e-8,0.0010555,0.00004317878,0.9910731,0.0002518923],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005929802,0.9772969,0.0002110637,0.00002730122,0.01707991,0.001085068,0.00001424443,0.0000369395,0.004242596],"genre_scores_gemma":[0.0001381369,0.9943355,0.00003042642,0.00004176604,0.00009027504,0.00005145522,0.0004129144,0.00004747716,0.004852052],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5666858,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07086084042375505,"score_gpt":0.3099769169154281,"score_spread":0.239116076491673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}