{"id":"W2797967938","doi":"10.1038/s41577-018-0007-5","title":"Understanding the drivers of MHC restriction of T cell receptors","year":2018,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":276,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council","keywords":"T-cell receptor; Major histocompatibility complex; Biology; MHC restriction; T cell; MHC class I; Computational biology; Germline; Genetics; Cell biology; Antigen; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008660486,0.0008845756,0.001036504,0.001215753,0.0002803136,0.001572785,0.00149486,0.001794389,0.002841754],"category_scores_gemma":[0.0009252209,0.0003292488,0.0003403393,0.0011324,0.001290284,0.002736156,0.001255051,0.003072184,0.002022312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007896564,"about_ca_system_score_gemma":0.001061994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005450794,"about_ca_topic_score_gemma":0.0007459319,"domain_scores_codex":[0.9997754,0.0000339277,0.00002285144,0.00003890903,0.0000870298,0.00004192207],"domain_scores_gemma":[0.9995354,0.0002096068,0.00005804606,0.00001876408,0.0001167434,0.00006138315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001190916,0.00003570581,0.0002473404,0.009749271,0.00005822599,0.0003049806,0.00008040851,0.0005896189,0.007272781,0.02497533,0.07609285,0.8804743],"study_design_scores_gemma":[0.000007760748,0.00003442696,0.0005138007,0.001346486,0.00003854607,0.0007698144,0.00006338226,0.000100404,0.000743225,0.009209541,0.987159,0.00001357561],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001162906,0.9966271,0.0002910639,0.001042536,0.0008442894,0.000002093654,0.00001320359,0.000009501118,0.001053907],"genre_scores_gemma":[0.0009794929,0.996745,0.0001437327,0.0004861971,0.000897117,0.000003735364,0.00002774764,0.000001972488,0.0007150492],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002841754,"threshold_uncertainty_score":0.009506583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07086084042375505,"score_gpt":0.3099769169154281,"score_spread":0.239116076491673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}