{"id":"W2798032217","doi":"10.1161/atvb.36.suppl_1.163","title":"Abstract 163: Apabetalone (RVX-208) Has Anti-atherosclerotic, Anti-Thrombotic and Anti-Inflammatory Effects in Patients With Cardiovascular Disease (CVD)","year":2016,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"South Health Campus; Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Mace; Downregulation and upregulation; Peripheral blood mononuclear cell; Internal medicine; Epigenetics; Endocrinology; Chemistry; Medicine; Biology; Pharmacology; In vitro; Gene; Biochemistry; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001239974,0.0004292484,0.00035383,0.0001800975,0.000139729,0.0002528397,0.0001474354,0.0003427227,0.008103904],"category_scores_gemma":[0.0001101384,0.00009669578,0.0002158992,0.0001785522,0.0001186568,0.00008638795,0.0001206699,0.0005040418,0.001748218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001670692,"about_ca_system_score_gemma":0.0002428637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003378523,"about_ca_topic_score_gemma":0.0004966583,"domain_scores_codex":[0.9999449,0.00001252842,0.000006618108,0.00001248875,0.0000115963,0.00001184442],"domain_scores_gemma":[0.9999369,0.000009245253,0.00001436427,0.000004813278,0.00001246442,0.00002202533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01204534,0.0007356232,0.003132134,0.000594027,0.00008988845,0.0004332938,0.00003057776,0.0001617803,0.9250352,0.0001358229,0.003226772,0.05437954],"study_design_scores_gemma":[0.006321042,0.05378877,0.1400705,0.0001145446,0.0005027709,0.003673156,0.0001029876,0.0008018856,0.7512203,0.0003117511,0.0430581,0.00003407895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797311,0.007481249,0.001097751,0.001130419,0.0003770838,0.0001795458,0.003702207,0.0002092406,0.006091367],"genre_scores_gemma":[0.9718874,0.003852301,0.001732433,0.0006902536,0.0003109932,0.0001530291,0.005073018,0.00002528049,0.01627526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008103904,"threshold_uncertainty_score":0.02711028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225431288379571,"score_gpt":0.2074118360170887,"score_spread":0.195157523133293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}