{"id":"W2798042944","doi":"10.1161/circ.132.suppl_3.13694","title":"Abstract 13694: Hsf1 Attenuates Pressure Overload Induced-cardiac Fibrosis via Inhibiting Smad3 Phosphorylation and Nuclear Translocation","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"","keywords":"Medicine; Pressure overload; Phosphorylation; Chromosomal translocation; Cardiology; HSF1; Fibrosis; Internal medicine; Cell biology; Pharmacology; Heart failure; Cardiac hypertrophy; Heat shock protein; Hsp70; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743923,0.0006892128,0.0005201155,0.0002914704,0.0002260125,0.0002488239,0.0003399942,0.0005362242,0.01252154],"category_scores_gemma":[0.00009823523,0.0001659141,0.000406469,0.0001971935,0.0004054721,0.0002924755,0.0002136713,0.001310128,0.001569758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951824,"about_ca_system_score_gemma":0.0004535993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000370352,"about_ca_topic_score_gemma":0.0004217616,"domain_scores_codex":[0.9998912,0.00001415083,0.00001183632,0.00001991624,0.00003543527,0.0000275567],"domain_scores_gemma":[0.9999269,0.000007036715,0.00002312676,0.000006490202,0.000009426903,0.00002694253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004351544,0.000751944,0.0003823644,0.0006200654,0.0000745648,0.0002149518,0.00004535105,0.000175856,0.9780006,0.0003178591,0.001579409,0.01348528],"study_design_scores_gemma":[0.001570956,0.009637786,0.0118874,0.00008014478,0.0001657711,0.001021381,0.00009795563,0.001184973,0.9605552,0.0003873038,0.01338977,0.00002134496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745678,0.01014779,0.004233614,0.001555042,0.0005598767,0.0001443625,0.003005467,0.0005940761,0.005192026],"genre_scores_gemma":[0.9640409,0.005610366,0.003386962,0.0005879789,0.0002562421,0.0003103148,0.003412553,0.00006277795,0.02233188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01252154,"threshold_uncertainty_score":0.04188871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02894438995326945,"score_gpt":0.2549224620390632,"score_spread":0.2259780720857937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}