{"id":"W2798054859","doi":"10.1200/jco.2018.36.4_suppl.560","title":"A phase Ib study of safety and clinical activity of atezolizumab (A) and cobimetinib (C) in patients (pts) with metastatic colorectal cancer (mCRC).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Colorectal cancer; Rash; Clinical endpoint; Atezolizumab; Gastroenterology; Microsatellite instability; Phases of clinical research; Adverse effect; Refractory (planetary science); Oncology; Cancer; Surgery; Chemotherapy; Clinical trial; Nivolumab; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001928392,0.0001589456,0.002457135,0.0001192141,0.00003764356,0.000002858881,0.00006671659,0.0001309177,0.00004342279],"category_scores_gemma":[0.001434627,0.00009594799,0.0001464595,0.0001813685,0.000843642,0.00007890787,0.00008705561,0.0004773836,3.043328e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168101,"about_ca_system_score_gemma":0.0007262131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502143,"about_ca_topic_score_gemma":0.003765315,"domain_scores_codex":[0.9964845,0.000609146,0.002163503,0.0002412488,0.0003274715,0.0001741424],"domain_scores_gemma":[0.9950035,0.00208416,0.001949618,0.0001071624,0.0006414072,0.0002141061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1036246,0.02124185,0.6562277,0.00003077397,0.001311871,0.00007954937,0.0005726015,4.313864e-7,0.00001837588,0.000002532586,0.00003893163,0.2168508],"study_design_scores_gemma":[0.07211334,0.2283911,0.6974505,0.00009607887,0.0009799036,0.00002246328,0.0003630128,0.00003441584,0.00004418378,0.000009147821,0.0004386337,0.00005717224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980418,0.0002660239,0.000005946371,0.0003667634,0.0003160202,0.000600582,0.00002008492,0.000002337043,0.0003804041],"genre_scores_gemma":[0.998318,0.00106011,0.0003526504,0.00008956939,0.0001453088,0.000006552554,6.112098e-7,0.00001077462,0.00001639417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2167936,"threshold_uncertainty_score":0.3912646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027352998852519,"score_gpt":0.5005962849997099,"score_spread":0.3978609851144579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}