{"id":"W2798171299","doi":"10.1021/acsinfecdis.8b00001","title":"Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Structural Genomics Consortium; University of Toronto; McMaster University","funders":"Argonne National Laboratory; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Canada Research Chairs; Achaogen","keywords":"Aminoglycoside; Sisomicin; Microbiology; Chemistry; Enzyme; Antibiotics; Biochemistry; Biology; Gentamicin; Tobramycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522045,0.0003579396,0.0003802077,0.0001820306,0.00008112174,0.0003835939,0.0001812955,0.0002469907,0.0005705408],"category_scores_gemma":[0.0002493395,0.0001012169,0.0002041825,0.0001896769,0.0001341718,0.0002509914,0.0001997535,0.0003495232,0.0002626562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881824,"about_ca_system_score_gemma":0.0001785876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004051889,"about_ca_topic_score_gemma":0.0005154322,"domain_scores_codex":[0.9997568,0.00003471965,0.00003397688,0.00004188125,0.00009343147,0.00003922705],"domain_scores_gemma":[0.9997815,0.00003513863,0.00007813382,0.0000374321,0.00003872488,0.00002895832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003221583,0.000007822963,0.0001612347,0.00001015197,0.000002215612,0.00001000066,0.000003439306,0.00003152242,0.9988853,0.000006498968,0.000004176705,0.0008452891],"study_design_scores_gemma":[0.000005959705,0.0005873041,0.005705015,0.000003299709,0.00001508361,0.0001946127,0.000008636319,0.0001750722,0.9919733,0.00000946176,0.001319407,0.000002882631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956836,0.001043777,0.002054849,0.00003286595,0.000007705084,0.00002306992,0.0002981547,0.0000703259,0.000785626],"genre_scores_gemma":[0.9950629,0.0006331515,0.002018414,0.00003737272,0.000007276456,0.00002135706,0.0008937536,0.0000212812,0.001304583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005705408,"threshold_uncertainty_score":0.00190866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009760595528703285,"score_gpt":0.2545294960460325,"score_spread":0.2447689005173292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}