{"id":"W2798171299","doi":"10.1021/acsinfecdis.8b00001","title":"Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Structural Genomics Consortium; University of Toronto; McMaster University","funders":"Argonne National Laboratory; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Canada Research Chairs; Achaogen","keywords":"Aminoglycoside; Sisomicin; Microbiology; Chemistry; Enzyme; Antibiotics; Biochemistry; Biology; Gentamicin; Tobramycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009225477,0.000297315,0.0002550319,0.00007900493,0.0003151232,0.00009668832,0.0002506784,0.0001886888,0.00002158679],"category_scores_gemma":[0.0004008497,0.0002946159,0.0001177131,0.0001855761,0.0004116513,0.00001932056,0.0001888593,0.0001106961,0.00006594641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006382644,"about_ca_system_score_gemma":0.0001466202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005816518,"about_ca_topic_score_gemma":0.0001365293,"domain_scores_codex":[0.9984524,0.0001009261,0.0002266537,0.0005961549,0.0001693646,0.0004544979],"domain_scores_gemma":[0.9988004,0.00003850568,0.0001595236,0.0006887151,0.0001458945,0.0001669481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001791468,0.0002667572,0.3756673,0.00005793895,0.0001436335,0.0000179879,0.00003008925,0.00002749892,0.6138341,0.0001659507,0.004971744,0.004637823],"study_design_scores_gemma":[0.0008809477,0.0004791346,0.2984934,0.00008046053,0.00009819983,0.00002508186,0.000058776,0.0001119608,0.6945856,0.0001284191,0.00446922,0.0005887192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933041,0.0004433494,0.0007059723,0.00004569648,0.0004458719,0.0002532046,0.00008818929,0.0001099486,0.004603666],"genre_scores_gemma":[0.9976975,0.0003285539,0.00007173421,0.0004810929,0.0008544349,0.000005046878,0.0001125332,0.00005511551,0.0003940398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08075153,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009760595528703285,"score_gpt":0.2545294960460325,"score_spread":0.2447689005173292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}