{"id":"W2798201176","doi":"10.1016/j.canlet.2018.04.009","title":"Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells","year":2018,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Nigella sativa pharmacological applications","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"College of Medicine and Health Sciences, United Arab Emirates University; National Science Foundation, United Arab Emirates; United Arab Emirates University; Terry Fox Research Institute; Al Jalila Foundation","keywords":"Thymoquinone; Senescence; Cyclin-dependent kinase; Biology; Gene knockdown; Cancer research; Apoptosis; Cell biology; Glioma; Cell cycle; Cyclin; Small hairpin RNA; Retinoblastoma protein; DNA damage; Biochemistry; Antioxidant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319553,0.0002098301,0.0003068514,0.0002025849,0.00009821533,0.00002150085,0.0001856894,0.0001252896,0.0008338374],"category_scores_gemma":[0.00002653903,0.000195038,0.00005855131,0.0004756924,0.0002364134,0.0001006614,0.00006760088,0.000306994,0.0001145992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720421,"about_ca_system_score_gemma":0.00007617733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003609741,"about_ca_topic_score_gemma":0.0001623727,"domain_scores_codex":[0.9980845,0.0001041477,0.0004429701,0.0005472918,0.0003300242,0.0004910287],"domain_scores_gemma":[0.9992511,0.0000884141,0.00007546379,0.0003332774,0.00007556473,0.0001761779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009132743,0.0001587299,0.01037872,0.00003912182,0.0000107166,0.0001264654,0.0006594001,0.0000290151,0.9870254,0.0002195236,0.0008529653,0.0004085567],"study_design_scores_gemma":[0.001466142,0.0001094465,0.05023348,0.0001340361,0.00003534356,0.00001113428,0.00008707119,0.0005333213,0.9465726,0.0001950995,0.0004026609,0.0002196391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892985,0.00008009218,0.0009296184,0.008115884,0.0002736268,0.0007316319,0.0000106012,0.00005902863,0.0005010125],"genre_scores_gemma":[0.9956822,0.000005764216,0.0002792441,0.003153183,0.000443962,0.0003319597,0.00001244346,0.00002818958,0.00006307782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04045283,"threshold_uncertainty_score":0.9129935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925755942208634,"score_gpt":0.3337378314053764,"score_spread":0.3044802719832901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}