{"id":"W2798320941","doi":"10.1101/313767","title":"Substrate binding allosterically relieves autoinhibition of the TRIB1 pseudokinase","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Georgia Advanced Computing Resource Center, University of Georgia; Novartis Pharma; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Royal Society; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Wellcome Trust; Royal Society Te Apārangi; University of Otago; Australian Synchrotron; New Zealand Government; Health Research Council of New Zealand; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Ministero dello Sviluppo Economico; Australian Nuclear Science and Technology Organisation; University of Georgia; Pfizer","keywords":"Ubiquitin ligase; Allosteric regulation; Ubiquitin; Cell biology; Transcription factor; Biology; Substrate (aquarium); Binding site; Plasma protein binding; Phosphorylation; Chemistry; Biophysics; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003179726,0.000319697,0.0003843368,0.0001946763,0.000514815,0.0007039419,0.0004416255,0.0004316969,0.03972952],"category_scores_gemma":[0.001541654,0.0001208177,0.0001908516,0.0001114705,0.0002438349,0.0004657209,0.0003399842,0.0007377238,0.009001833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005660885,"about_ca_system_score_gemma":0.0004605365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002739613,"about_ca_topic_score_gemma":0.0006211341,"domain_scores_codex":[0.999793,0.00002375151,0.00002310464,0.00003280757,0.0001012674,0.00002600959],"domain_scores_gemma":[0.9991742,0.0002792946,0.0001355255,0.0000633904,0.0002267304,0.0001207827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001972557,0.0002433687,0.000633483,0.001140322,0.00003807239,0.002087199,0.0004032122,0.0007072245,0.2409679,0.01076641,0.6746548,0.06638538],"study_design_scores_gemma":[0.0002794925,0.0003882151,0.004385712,0.0001036626,0.00004807835,0.001433781,0.0003329436,0.005224478,0.2756636,0.004009928,0.7080385,0.00009163361],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3462304,0.007729157,0.02992881,0.1190303,0.2661488,0.0005122855,0.008528904,0.007849274,0.2140421],"genre_scores_gemma":[0.7566138,0.002227193,0.01064606,0.007170641,0.01793432,0.0002400087,0.003562355,0.001739453,0.1998661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03972952,"threshold_uncertainty_score":0.1329085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00894599918682204,"score_gpt":0.2142029134630898,"score_spread":0.2052569142762677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}