{"id":"W2798736647","doi":"10.1101/306472","title":"The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Research Council Canada; Western Economic Diversification Canada; National Science Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Canadian Institutes of Health Research; High Performance Research Computing, Texas A and M University; Susan G. Komen for the Cure; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Texas AgriLife Research; Breast Cancer Research Foundation; U.S. Department of Defense; National Institutes of Health","keywords":"Selective estrogen receptor modulator; Tamoxifen; Antiestrogen; Estrogen receptor; Cancer research; Palbociclib; Breast cancer; Estrogen receptor alpha; Raloxifene; Cancer; Metastatic breast cancer; Biology; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006786098,0.0007488722,0.0005667417,0.0001475538,0.0002945761,0.0002180004,0.001044729,0.001049518,0.00001312693],"category_scores_gemma":[0.00007224677,0.000640982,0.0002299356,0.0004395503,0.0002398621,0.00001435699,0.001038872,0.0005485584,0.00006882882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555056,"about_ca_system_score_gemma":0.0005359619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001223309,"about_ca_topic_score_gemma":0.00009460391,"domain_scores_codex":[0.9963406,0.0002509053,0.0006274894,0.001377599,0.0004090903,0.0009943328],"domain_scores_gemma":[0.9970293,0.00004038589,0.0003458345,0.001862113,0.0002907507,0.0004315969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006331403,0.0001135131,0.001554381,0.0001154574,0.000215009,0.0000479635,0.00001364425,0.00006906438,0.9912741,0.00004040502,0.005919691,0.00000368077],"study_design_scores_gemma":[0.000944344,0.0001326448,0.1250655,0.0004671984,0.00009562243,8.891634e-8,0.000003358385,0.00004214544,0.8526499,0.000003248788,0.01951138,0.001084647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827245,0.01313205,0.00009493756,0.0008375765,0.001448041,0.001063411,0.0005846368,0.00009147762,0.00002339526],"genre_scores_gemma":[0.9909614,0.006036261,0.0007276974,0.0004251029,0.001116369,0.0004503609,0.000002047476,0.0001877539,0.00009302836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1386242,"threshold_uncertainty_score":0.9996042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005676622637720226,"score_gpt":0.2208302700449879,"score_spread":0.2151536474072676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}