{"id":"W2798736647","doi":"10.1101/306472","title":"The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Research Council Canada; Western Economic Diversification Canada; National Science Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Canadian Institutes of Health Research; High Performance Research Computing, Texas A and M University; Susan G. Komen for the Cure; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Texas AgriLife Research; Breast Cancer Research Foundation; U.S. Department of Defense; National Institutes of Health","keywords":"Selective estrogen receptor modulator; Tamoxifen; Antiestrogen; Estrogen receptor; Cancer research; Palbociclib; Breast cancer; Estrogen receptor alpha; Raloxifene; Cancer; Metastatic breast cancer; Biology; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481479,0.0001546725,0.0002431543,0.00009627816,0.0001531953,0.0001916338,0.0002466118,0.0002318347,0.001506674],"category_scores_gemma":[0.0001004789,0.0001041567,0.0002853696,0.0001252142,0.0001631632,0.00009081184,0.00014891,0.0004334249,0.0005070889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200902,"about_ca_system_score_gemma":0.000188272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008639712,"about_ca_topic_score_gemma":0.001062765,"domain_scores_codex":[0.9998912,0.00001556437,0.00001246895,0.00001414673,0.00004644996,0.00002012547],"domain_scores_gemma":[0.9999403,0.000008272668,0.0000197426,0.000009210926,0.000009417342,0.00001304941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008699649,0.00002906947,0.0001883293,0.0000277202,0.000008450482,0.00004641582,0.000008026825,0.0001097262,0.9980401,0.00007464366,0.0001057012,0.001274818],"study_design_scores_gemma":[0.00004957494,0.000362602,0.002052073,0.000004771799,0.00001667974,0.000382315,0.00002585812,0.00138487,0.9876518,0.00003774528,0.008026025,0.000005648786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927262,0.001297841,0.002983555,0.0002909681,0.0000586845,0.00003762942,0.000676785,0.0001121598,0.001816244],"genre_scores_gemma":[0.9944436,0.0005467666,0.002192072,0.00009108058,0.000007182512,0.00002219602,0.0006519601,0.00001883245,0.002026235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506674,"threshold_uncertainty_score":0.005040348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005676622637720226,"score_gpt":0.2208302700449879,"score_spread":0.2151536474072676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}