{"id":"W2799247383","doi":"10.1101/312447","title":"The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"Latency (audio); Cell biology; Biology; Population; Ex vivo; In vitro; In vivo; Provirus; Apoptosis; Caspase; Virology; Immunology; Chemistry; Molecular biology; Programmed cell death; Gene; Medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008478079,0.0006485993,0.0005821012,0.0002171286,0.001175377,0.0002105779,0.0009819035,0.0007487374,0.0004882924],"category_scores_gemma":[0.0002269643,0.0004933238,0.000334575,0.0003160041,0.0006190301,0.00007401263,0.00097668,0.001188061,0.008186805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005008732,"about_ca_system_score_gemma":0.0006530317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728858,"about_ca_topic_score_gemma":0.000006473929,"domain_scores_codex":[0.9963543,0.000494077,0.0005878118,0.0011272,0.000197862,0.001238723],"domain_scores_gemma":[0.9969064,0.0001693312,0.0003494313,0.001891957,0.0004997182,0.0001831732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006124674,0.001179581,0.01565083,0.0005510086,0.005454166,0.0005213314,0.0002216238,0.000007610813,0.8431696,0.0005580192,0.1319206,0.0001531202],"study_design_scores_gemma":[0.00237868,0.0003835675,0.07993846,0.0007469872,0.00053388,3.153515e-7,0.00002043465,0.00002683293,0.4762267,0.00001223977,0.438459,0.001272931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95495,0.03134014,0.0004063674,0.003828882,0.004919416,0.002334506,0.001429973,0.0005704727,0.0002201852],"genre_scores_gemma":[0.9959468,0.002173171,0.0006037099,0.0002388715,0.0002500236,0.0002453337,0.000003996249,0.0001065958,0.0004314502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.366943,"threshold_uncertainty_score":0.9997519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702424770445594,"score_gpt":0.2331266076176533,"score_spread":0.2161023599131974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}