{"id":"W2799306261","doi":"10.1016/j.jid.2018.04.028","title":"Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Recessive Dystrophic Epidermolysis Bullosa in a Xenograft Model","year":2018,"lang":"en","type":"letter","venue":"Journal of Investigative Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Hospital for Sick Children; Institut National de la Santé et de la Recherche Médicale; Institut des maladies génétiques Imagine; Dystrophic Epidermolysis Bullosa Research Association","keywords":"Mesenchymal stem cell; Medicine; Anchoring fibrils; Stromal cell; Epidermolysis bullosa; Epidermolysis bullosa dystrophica; Pathology; Bone marrow; Cancer research; Dermatology; Basement membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0005762052,0.0005279529,0.001384709,0.0008381831,0.00008205554,0.00002186421,0.0006131891,0.002066542,0.00004262948],"category_scores_gemma":[0.0006881188,0.0004740577,0.0004668073,0.00038267,0.002107268,0.0000192921,0.0002396286,0.00241752,0.000008781762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007932325,"about_ca_system_score_gemma":0.000955997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003020139,"about_ca_topic_score_gemma":0.00002357842,"domain_scores_codex":[0.9952101,0.001473217,0.001534848,0.0005775036,0.000470412,0.0007339055],"domain_scores_gemma":[0.9964177,0.0001549905,0.001948015,0.0004397233,0.0008495147,0.0001900783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003292694,0.0001003839,0.000489029,0.0002103323,0.0004866009,0.006450702,0.0002360186,0.0002520026,0.717148,0.000008910599,0.2742015,0.00008716693],"study_design_scores_gemma":[0.001445335,0.001458206,0.0001111897,0.0002632139,0.000166366,0.0339584,0.0001931927,0.001362802,0.9558446,0.0009150803,0.003795922,0.0004856381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517745,0.001563615,0.000630656,0.04489178,0.0005863911,0.0003052033,0.00007775355,0.000005773992,0.0001643689],"genre_scores_gemma":[0.9772724,0.0004908916,0.002856184,0.01650836,0.001971942,0.00002997346,0.0003946611,0.00009016454,0.0003854199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2704056,"threshold_uncertainty_score":0.9998839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952315007821373,"score_gpt":0.2625530799010731,"score_spread":0.2430299298228593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}