{"id":"W2799371896","doi":"10.1016/j.jcyt.2018.02.010","title":"T cells engineered with T-cell antigen coupler (TAC) receptors display robust efficacy against solid and liquid tumor xenografts in the absence of any toxicity","year":2018,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; T-cell receptor; Antigen; Receptor; Cell biology; T cell; Major histocompatibility complex; Chemistry; Immunology; Cancer research; Biology; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006343871,0.0002717996,0.0004631998,0.0001894935,0.00008703169,0.00003459074,0.0002898911,0.0001002388,0.0006067617],"category_scores_gemma":[0.00002579473,0.0001744714,0.00007833602,0.0005968681,0.0005531281,0.00007673917,0.0000302889,0.0003280677,0.00001812639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006000532,"about_ca_system_score_gemma":0.0001278367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005883734,"about_ca_topic_score_gemma":0.00007959088,"domain_scores_codex":[0.9981276,0.0001149828,0.0003389557,0.0004034129,0.0005175212,0.0004975244],"domain_scores_gemma":[0.998735,0.0002245049,0.0001098312,0.0006176183,0.0001564095,0.0001567137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002507447,0.0005232891,0.007707253,0.00007292978,0.00006594917,0.00003550154,0.00362467,0.00009957155,0.9836277,0.000009062414,0.0005354219,0.001191216],"study_design_scores_gemma":[0.005774315,0.004205735,0.02789746,0.0002620912,0.00001528455,0.00003509577,0.0005218086,0.001559126,0.9513646,0.000003250374,0.008041513,0.0003197638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967522,0.000441391,0.0001869094,0.0002586319,0.000110644,0.001053888,0.00001202798,0.00003790861,0.001146384],"genre_scores_gemma":[0.9965163,0.001302656,0.0005763855,0.0005800845,0.0002893712,0.00002728289,0.00001015363,0.00006517502,0.0006325354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03226313,"threshold_uncertainty_score":0.7114735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191419146780279,"score_gpt":0.2796416926210811,"score_spread":0.2604997779430532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}