{"id":"W2799371896","doi":"10.1016/j.jcyt.2018.02.010","title":"T cells engineered with T-cell antigen coupler (TAC) receptors display robust efficacy against solid and liquid tumor xenografts in the absence of any toxicity","year":2018,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; T-cell receptor; Antigen; Receptor; Cell biology; T cell; Major histocompatibility complex; Chemistry; Immunology; Cancer research; Biology; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514771,0.0004109839,0.0002605752,0.0002667216,0.0001300455,0.0004480215,0.0001770381,0.0004011775,0.001251657],"category_scores_gemma":[0.0001229669,0.00009427418,0.0001859851,0.0001595712,0.0002784538,0.0002264195,0.0001589395,0.0006633954,0.0004884197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083534,"about_ca_system_score_gemma":0.0001475471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007852576,"about_ca_topic_score_gemma":0.0007782306,"domain_scores_codex":[0.9998453,0.00002183936,0.00001058496,0.00002972094,0.00004910259,0.00004342684],"domain_scores_gemma":[0.9998734,0.00002979284,0.00003486592,0.00002081228,0.00001490373,0.00002618861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007304182,0.00004195258,0.00006797748,0.00001549196,0.000003943387,0.0000201095,0.00001321389,0.0001114556,0.9982273,0.0001503228,0.00009035034,0.001184795],"study_design_scores_gemma":[0.00001252722,0.000200741,0.0003383671,0.000001473176,0.000009288484,0.00005825896,0.00000572201,0.0003713469,0.9981741,0.00001503243,0.0008115777,0.000001685915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888608,0.0009705166,0.005401453,0.00008460278,0.00004258386,0.00006208181,0.0002869539,0.0003076576,0.00398348],"genre_scores_gemma":[0.9952698,0.0002882136,0.001684677,0.00002833468,0.000008081794,0.00002890051,0.0003386659,0.00004090098,0.002312392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251657,"threshold_uncertainty_score":0.004187226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191419146780279,"score_gpt":0.2796416926210811,"score_spread":0.2604997779430532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}