{"id":"W2799386757","doi":"10.1186/s12885-018-4227-7","title":"Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"European Organisation for Research and Treatment of Cancer; University of the West of England","keywords":"DU145; Alternative splicing; Splicing factor; Kinase; RNA splicing; Cancer research; splice; Biology; Exon; Molecular biology; Cancer cell; Cell biology; Cancer; Gene; Genetics; RNA; LNCaP","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008839896,0.0002012926,0.0002455846,0.0001645911,0.0002264275,0.0002449251,0.0001431255,0.0001834392,0.001290386],"category_scores_gemma":[0.00009861111,0.0001091222,0.0003039177,0.0003489233,0.0001791709,0.0001354211,0.0001699969,0.0004553854,0.0002810463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003636832,"about_ca_system_score_gemma":0.000317131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00390326,"about_ca_topic_score_gemma":0.003750826,"domain_scores_codex":[0.9998649,0.000009457004,0.00001142577,0.00002926258,0.00005449043,0.00003038309],"domain_scores_gemma":[0.9999019,0.00001534367,0.00003262375,0.00001117905,0.00001850198,0.00002040016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299334,0.00001588861,0.0009246701,0.00002811028,0.000007387656,0.00006825148,0.00002433767,0.00005177238,0.9976515,0.00002510276,0.00005482879,0.001018153],"study_design_scores_gemma":[0.000009865695,0.0003339317,0.05670031,0.000004708825,0.00002646438,0.0006343177,0.00008831824,0.0006906014,0.9391159,0.0000479577,0.002340216,0.000007347639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994211,0.001484329,0.001924163,0.0001039311,0.00001752354,0.00001606778,0.001181035,0.00007621729,0.0009856833],"genre_scores_gemma":[0.9949155,0.0007650997,0.001376194,0.00006258202,0.000006806868,0.00002995228,0.001401543,0.00002137777,0.001421084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00390326,"threshold_uncertainty_score":0.007761121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693633011817612,"score_gpt":0.3203052516313297,"score_spread":0.2933689215131536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}