{"id":"W2799416165","doi":"10.4049/jimmunol.1701670","title":"eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Children's Hospital of Eastern Ontario; University of Ottawa; Jewish General Hospital; Institut National de la Recherche Scientifique","funders":"","keywords":"Cyclooxygenase; Psychological repression; EIF4E; Limit (mathematics); Interleukin; Immunology; Chemistry; Medicine; Cytokine; Biochemistry; Translation (biology); Enzyme; Gene expression; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138598,0.000523583,0.0003709651,0.000317368,0.0001425498,0.0003270154,0.000190718,0.000311797,0.001457702],"category_scores_gemma":[0.0001618068,0.0001840023,0.0002697275,0.0001058562,0.0002772942,0.0002095981,0.0002231045,0.0004818571,0.0003552642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235071,"about_ca_system_score_gemma":0.0002037255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001654526,"about_ca_topic_score_gemma":0.00027148,"domain_scores_codex":[0.9998429,0.00001851245,0.00001309705,0.00003711507,0.00003973005,0.00004870316],"domain_scores_gemma":[0.9998154,0.00002232079,0.00007522304,0.00001693409,0.00002105428,0.00004908277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002076285,0.0000217372,0.0001234664,0.00003538671,0.000003567345,0.0000175388,0.000004343825,0.0000429164,0.9987524,0.00006430325,0.00003398523,0.0006927027],"study_design_scores_gemma":[0.00008515507,0.0005288745,0.008462456,0.00001409602,0.00002294789,0.0002257904,0.00003010788,0.001058698,0.9841726,0.0001791164,0.005209699,0.00001042038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882483,0.00507253,0.004298697,0.0002585512,0.00009721013,0.00005035669,0.0004734638,0.0001502025,0.001350613],"genre_scores_gemma":[0.9893103,0.001539603,0.004438516,0.0001281305,0.00003855966,0.00009907669,0.0004649491,0.0000356705,0.003945109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457702,"threshold_uncertainty_score":0.004876435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499370938421975,"score_gpt":0.2927324090866926,"score_spread":0.2677386997024728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}