{"id":"W2799486369","doi":"10.1371/journal.ppat.1006998","title":"PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Eye Institute; Hospital for Sick Children; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Toronto","keywords":"Biochemistry; Escherichia coli; Biofilm; Periplasmic space; Microbiology; Glycoside hydrolase; Staphylococcus epidermidis; Operon; Hydrolase; Biology; Chemistry; Bacteria; Enzyme; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007100206,0.0004329031,0.0002014975,0.0001563016,0.000167199,0.0002746654,0.0001747898,0.0003347729,0.0007320012],"category_scores_gemma":[0.0001198784,0.0001256907,0.0002296468,0.000151278,0.0002218612,0.0001952475,0.0003301449,0.0005568935,0.0005341201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994878,"about_ca_system_score_gemma":0.0001775896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008730016,"about_ca_topic_score_gemma":0.000828595,"domain_scores_codex":[0.9999049,0.00001272053,0.000006327395,0.00002251957,0.00003577599,0.00001778491],"domain_scores_gemma":[0.9999311,0.0000103702,0.00001788358,0.000009801748,0.000008371145,0.00002249015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006575981,0.00002157001,0.0008931124,0.00003487192,0.000003567283,0.00008538037,0.00001466828,0.00003954993,0.9974557,0.00006023391,0.00003515678,0.001290524],"study_design_scores_gemma":[0.00002347953,0.0002424601,0.04113272,0.000009303349,0.00002572836,0.002233949,0.00008940098,0.001509038,0.9452782,0.000177019,0.009266045,0.0000126736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911281,0.001100198,0.005028469,0.0001718117,0.00002946738,0.00002326493,0.001055908,0.0001137482,0.001349048],"genre_scores_gemma":[0.9857961,0.0006646825,0.006283442,0.0001508827,0.00001290082,0.0000312131,0.004393417,0.0000358004,0.002631662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008730016,"threshold_uncertainty_score":0.002448797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119886035691096,"score_gpt":0.2173091315988556,"score_spread":0.2061102712419446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}