{"id":"W2799486369","doi":"10.1371/journal.ppat.1006998","title":"PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Eye Institute; Hospital for Sick Children; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Toronto","keywords":"Biochemistry; Escherichia coli; Biofilm; Periplasmic space; Microbiology; Glycoside hydrolase; Staphylococcus epidermidis; Operon; Hydrolase; Biology; Chemistry; Bacteria; Enzyme; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001836028,0.0003964835,0.0003875897,0.00009682862,0.0002161742,0.00008060577,0.000283226,0.0006274888,0.00006687432],"category_scores_gemma":[0.00009035431,0.0003568582,0.0001067131,0.000142918,0.000608003,0.000006184394,0.0003976755,0.0001593036,0.00002272801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001962016,"about_ca_system_score_gemma":0.00007258308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005292675,"about_ca_topic_score_gemma":0.0006325321,"domain_scores_codex":[0.9979766,0.00014299,0.0003325222,0.0007790326,0.0001424935,0.0006263875],"domain_scores_gemma":[0.9988912,0.00001594942,0.0001644717,0.0006160383,0.00009538684,0.0002168995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004507991,0.0001165244,0.005674629,0.0000140391,0.0001230143,0.0000340927,0.0001058116,7.039088e-8,0.9909586,0.00004334067,0.0001610324,0.002318053],"study_design_scores_gemma":[0.001365469,0.001715056,0.009818176,0.00002200075,0.00007228815,0.0001304705,0.00015391,0.00002055076,0.9728681,0.00007712137,0.01327129,0.0004855863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970114,0.0006431918,0.00006794877,0.0007286607,0.0003539027,0.0003861121,0.0005729867,0.0000752268,0.0001605663],"genre_scores_gemma":[0.9950953,0.000462574,0.002373268,0.0004142537,0.0007645196,0.00003712108,0.0006290216,0.00006450036,0.0001594714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01809051,"threshold_uncertainty_score":0.9998884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119886035691096,"score_gpt":0.2173091315988556,"score_spread":0.2061102712419446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}