{"id":"W2799530874","doi":"10.1074/jbc.ra118.002889","title":"Frequent interferon regulatory factor 1 (IRF1) binding at remote elements without histone modification","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Prince Edward Island; Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Dalhousie University","funders":"Canadian Cancer Society Research Institute; Krembil Foundation","keywords":"Biology; Chromatin; Histone; Chromatin remodeling; Interferon regulatory factors; IRF1; SWI/SNF; Histone code; Chromatin immunoprecipitation; Transcription factor; SMARCA4; Cell biology; Enhancer; Histone H4; P300-CBP Transcription Factors; Genetics; Promoter; Nucleosome; Histone Acetyltransferases; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089002,0.0003198552,0.0003109874,0.0002902084,0.0002384039,0.000247727,0.0002643281,0.0002878373,0.003257524],"category_scores_gemma":[0.0002725319,0.0001929762,0.0004306706,0.0002253514,0.000283579,0.0002444812,0.0004424966,0.0004753728,0.001008945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235265,"about_ca_system_score_gemma":0.0001579571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002953472,"about_ca_topic_score_gemma":0.0006234382,"domain_scores_codex":[0.9996462,0.00002736839,0.00001531776,0.0001468648,0.00007824178,0.00008591188],"domain_scores_gemma":[0.9997912,0.0000451566,0.00006299237,0.00004369163,0.00002366121,0.0000331932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121117,0.00001440652,0.00378272,0.00004598543,0.00001518264,0.000091813,0.00003082629,0.00006506153,0.9911225,0.0001739643,0.00006809668,0.004477291],"study_design_scores_gemma":[0.00001826464,0.0002619263,0.08422531,0.00001815476,0.00005635295,0.001662553,0.0001175859,0.0009039418,0.9052399,0.000519974,0.00695903,0.00001703585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875607,0.001230657,0.008826009,0.00004957315,0.00002896318,0.00001913924,0.0004631268,0.0001449127,0.001677052],"genre_scores_gemma":[0.9929143,0.0003969403,0.003218757,0.000061065,0.00001348877,0.00002678217,0.00117027,0.00002763762,0.002170691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003257524,"threshold_uncertainty_score":0.01089746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708866920228994,"score_gpt":0.2856101556072217,"score_spread":0.2585214864049318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}