{"id":"W2799574682","doi":"10.1016/s1470-2045(18)30242-0","title":"Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort","year":2018,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":394,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of Calgary; McGill University; University of Toronto; Toronto General Hospital; University Health Network; Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute; Strategic Research Council; Canadian Institutes of Health Research; Brain Tumour Research; National Cancer Institute; Fondation de l'Hôpital de Montréal pour enfants; BC Cancer Foundation; Lékařská fakulta, Masarykova univerzita; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Masarykova Univerzita; Nationales Centrum für Tumorerkrankungen Heidelberg; Göteborgs Universitet; Universitetet i Oslo; Karolinska Institutet; Terry Fox Research Institute; Cancerfonden; Universität Zürich; Bundesministerium für Bildung und Forschung; Norges Forskningsråd; Semmelweis Egyetem; Bundesamt für Gesundheit; Pediatric Brain Tumor Foundation; Deutsche Krebshilfe; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Broad Institute; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Universidad Nacional Autónoma de México; Pediatric Oncology Group of Ontario; FH Foundation; Instituto Mexicano del Seguro Social; Colorado State University; Barncancerfonden; Ontario Institute for Cancer Research; University of Miami; European Molecular Biology Organization; University of Bern; Ministerstvo Zdravotnictví Ceské Republiky; Rockefeller University; Massachusetts Institute of Technology; Universität Basel; National Institutes of Health; Children's Hospital Foundation; John D. and Catherine T. MacArthur Foundation; Genome Canada; Garron Family Cancer Centre; European Commission; Sontag Foundation; Hospital for Sick Children; Genome British Columbia; Strategiske Forskningsråd; Cancer Research UK; World Health Organization; Deutsche Kinderkrebsstiftung; University of Chicago; University of California; Vetenskapsrådet; European Research Council; V Foundation for Cancer Research; Government of Ontario; Alexander and Margaret Stewart Trust; Deutsches Krebsforschungszentrum","keywords":"Medulloblastoma; Genetic predisposition; Retrospective cohort study; Medicine; Prospective cohort study; Cohort; Clinical trial; Oncology; Pediatrics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005622574,0.0005907755,0.0006952765,0.0009678247,0.0008680968,0.001053392,0.0008856543,0.0007068534,0.002837393],"category_scores_gemma":[0.009197021,0.0004738143,0.0009381889,0.001346846,0.001217014,0.0008903362,0.001196174,0.0007302211,0.0006612801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007017182,"about_ca_system_score_gemma":0.0009323406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002292607,"about_ca_topic_score_gemma":0.0024905,"domain_scores_codex":[0.9960484,0.001817104,0.000402343,0.001063046,0.0003801522,0.0002890146],"domain_scores_gemma":[0.9919822,0.001797828,0.002838411,0.001867067,0.0005955214,0.0009189473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003802365,0.0002363101,0.9926383,0.00003844351,0.0004312691,0.0002641666,0.0002291369,0.00006288495,0.0004686935,0.00007615206,0.0002099564,0.001542249],"study_design_scores_gemma":[0.0006810782,0.002881328,0.9923216,0.00003766589,0.0006630796,0.001581097,0.0003015863,0.0004052426,0.0002416301,0.0001454216,0.0007163148,0.00002421],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986269,0.0002972565,0.0002629498,0.00003515573,0.000006739718,0.00009535708,0.0004336482,0.000005821748,0.0002360101],"genre_scores_gemma":[0.9984326,0.0001087749,0.0003353401,0.00004552302,0.00001210857,0.0001169688,0.0008340262,0.000009342218,0.0001051933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005622574,"threshold_uncertainty_score":0.02973539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558688702811941,"score_gpt":0.3766558975379356,"score_spread":0.3410690105098162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}