{"id":"W2799608052","doi":"10.3324/haematol.2018.189852","title":"Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms","year":2018,"lang":"en","type":"article","venue":"Haematologica","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Janeway Children's Health and Rehabilitation Centre; Memorial University of Newfoundland; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Dexamethasone; Immunology; Medicine; Internal medicine; Antibody; Immune system; Immune tolerance; Factor IX; Antigen; Endocrinology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002748872,0.0002985289,0.0007109971,0.0002193362,0.0001643569,0.0000335824,0.0002310977,0.0002694705,0.002023963],"category_scores_gemma":[0.0001425021,0.0002037341,0.0001231203,0.0005845374,0.0002788785,0.0001061058,0.00009151956,0.0003549745,0.001852922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168784,"about_ca_system_score_gemma":0.00007914399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004849453,"about_ca_topic_score_gemma":0.00004123485,"domain_scores_codex":[0.997713,0.0001219597,0.0004040282,0.0006201375,0.0004206979,0.0007201661],"domain_scores_gemma":[0.9988763,0.0001617323,0.00008549882,0.0005010535,0.0001534684,0.0002218927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002153833,0.002663123,0.0473257,0.0006029665,0.000190313,0.004598577,0.00223103,0.000001063374,0.9176873,0.004027873,0.003371209,0.01514699],"study_design_scores_gemma":[0.005446357,0.002372792,0.04511319,0.0006351007,0.00005014672,0.001973787,0.0002815497,0.001162871,0.924934,0.01189982,0.005430156,0.0007002331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900706,0.0008363602,0.0006003519,0.002776864,0.000171717,0.001132869,0.000008177923,0.000170713,0.004232277],"genre_scores_gemma":[0.9902655,0.0002136325,0.007005096,0.0002432642,0.0001239148,0.0001097343,0.00001524855,0.00003275968,0.001990834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01444675,"threshold_uncertainty_score":0.9989243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04584113112229286,"score_gpt":0.3029143180218155,"score_spread":0.2570731868995226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}