{"id":"W2799617155","doi":"10.1016/j.biopha.2018.04.008","title":"IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis","year":2018,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"Janssen Research and Development; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Occludin; Interleukin 8; Ulcerative colitis; Colitis; Chemokine; Lactobacillus acidophilus; CXC chemokine receptors; MAPK/ERK pathway; Inflammatory bowel disease; Receptor; Inflammation; Immunology; Signal transduction; Chemistry; Medicine; Pharmacology; Tight junction; Internal medicine; Chemokine receptor; Probiotic; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004255919,0.0004575442,0.0003712008,0.0001890867,0.0002192971,0.00005815841,0.0003185111,0.0001748805,0.0004681167],"category_scores_gemma":[0.00001592245,0.0003810682,0.00008672481,0.0004273552,0.0006465368,0.00002168113,0.00005306688,0.0001984865,0.00003816517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008563015,"about_ca_system_score_gemma":0.0004139728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000718016,"about_ca_topic_score_gemma":0.0001399739,"domain_scores_codex":[0.9974272,0.0002333843,0.000509158,0.0007513114,0.0003566377,0.0007222585],"domain_scores_gemma":[0.9987648,0.00001736009,0.0002457621,0.0004358753,0.0002998031,0.0002363582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004735976,0.0002372087,0.0007790737,0.00004579738,0.0002149966,0.0001565292,0.0004762928,0.00002606306,0.9875596,0.00003923158,0.0006901287,0.005039061],"study_design_scores_gemma":[0.01766976,0.002910095,0.03291577,0.0002193773,0.0001554579,0.00006600196,0.0003830998,0.003624927,0.9321905,0.00006948147,0.008757056,0.001038499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858458,0.0003688732,0.0108583,0.0003353638,0.00047648,0.001249744,0.00006176968,0.00006938243,0.0007343103],"genre_scores_gemma":[0.9936486,0.0002528425,0.0006714129,0.002756144,0.001739203,0.000140463,0.0001705661,0.00009658372,0.0005242029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05536917,"threshold_uncertainty_score":0.9998641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007815302066221082,"score_gpt":0.2758878628607019,"score_spread":0.2680725607944808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}