{"id":"W2799617155","doi":"10.1016/j.biopha.2018.04.008","title":"IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis","year":2018,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"Janssen Research and Development; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Occludin; Interleukin 8; Ulcerative colitis; Colitis; Chemokine; Lactobacillus acidophilus; CXC chemokine receptors; MAPK/ERK pathway; Inflammatory bowel disease; Receptor; Inflammation; Immunology; Signal transduction; Chemistry; Medicine; Pharmacology; Tight junction; Internal medicine; Chemokine receptor; Probiotic; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008856569,0.0003092472,0.0003883862,0.0001626333,0.000112109,0.0001763295,0.0002136165,0.0003512606,0.001540076],"category_scores_gemma":[0.0000870134,0.00009880558,0.0001686421,0.0001456708,0.000155377,0.0002150103,0.0001674061,0.0007002775,0.0003577673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120019,"about_ca_system_score_gemma":0.0002113047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00030351,"about_ca_topic_score_gemma":0.0004981815,"domain_scores_codex":[0.9999089,0.00001292224,0.000008485576,0.00001481986,0.000019593,0.00003526175],"domain_scores_gemma":[0.9999714,0.000002468604,0.000006748734,0.000002575048,0.000003154822,0.00001371661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002287913,0.000310497,0.0001243391,0.0001020319,0.00001723177,0.00009729172,0.00001076732,0.0002087925,0.9879823,0.0001368233,0.0002242562,0.00849784],"study_design_scores_gemma":[0.0008092724,0.006937247,0.002878987,0.00001898032,0.0001328533,0.0004474538,0.00003883109,0.001946363,0.9804103,0.0001206729,0.006243895,0.00001509496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934953,0.003305057,0.001302837,0.0002479813,0.0001315613,0.00003413521,0.0001888099,0.0001076779,0.001186457],"genre_scores_gemma":[0.9932849,0.001879464,0.001924676,0.00009655151,0.00003410257,0.00004908598,0.0002832802,0.00001529085,0.002432575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540076,"threshold_uncertainty_score":0.005152047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007815302066221082,"score_gpt":0.2758878628607019,"score_spread":0.2680725607944808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}