{"id":"W2799684224","doi":"10.1016/j.cbpc.2018.04.003","title":"Effect of hemin, baicalein and heme oxygenase-1 (HO-1) enzyme activity inhibitors on Cd-induced accumulation of HO-1, HSPs and aggresome-like structures in Xenopus kidney epithelial cells","year":2018,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aggresome; Hemin; Heme oxygenase; Cell biology; Cilium; Biliverdin; Cytoprotection; Heat shock protein; Protoporphyrin; Xenopus; Chemistry; Heme; Baicalein; Biology; Biochemistry; Enzyme; Oxidative stress; Apoptosis; Pharmacology; Porphyrin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184155,0.0003461366,0.0004241261,0.0001972762,0.0002923872,0.000244671,0.0002570113,0.0003389479,0.00202351],"category_scores_gemma":[0.0001412801,0.0001738645,0.000349696,0.0002067079,0.0003003399,0.0002853895,0.0001471527,0.0008309975,0.000351725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006254474,"about_ca_system_score_gemma":0.0005056182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003460512,"about_ca_topic_score_gemma":0.005703259,"domain_scores_codex":[0.9998498,0.00002642603,0.00001964312,0.00003141375,0.00002191139,0.00005078476],"domain_scores_gemma":[0.9998247,0.00005489873,0.000024546,0.00001901172,0.00002061101,0.00005627549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000874819,0.0001523642,0.0001232621,0.00009586434,0.00001764686,0.0001283114,0.00005238874,0.00008904881,0.9972881,0.0002085522,0.0001663993,0.0008033811],"study_design_scores_gemma":[0.00006150997,0.0003330596,0.002950449,0.00000454976,0.00001499637,0.00009312953,0.00003941751,0.0005428588,0.9945881,0.00002805038,0.001338375,0.000005502312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930957,0.00189355,0.0007393602,0.0003219569,0.0001020536,0.00005445743,0.0008390759,0.000113892,0.002839968],"genre_scores_gemma":[0.9916015,0.0008993026,0.00118438,0.0001028246,0.00002102008,0.00006080991,0.0007180544,0.00002042842,0.005391549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003460512,"threshold_uncertainty_score":0.00688076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025473307525561,"score_gpt":0.3337385759717142,"score_spread":0.3082652684461532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}