{"id":"W2799710201","doi":"10.1186/s40169-018-0185-6","title":"Analyses of repeated failures in cancer therapy for solid tumors: poor tumor‐selective drug delivery, low therapeutic efficacy and unsustainable costs","year":2018,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":486,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Eye Institute; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; National Cancer Institute; University of Pennsylvania","keywords":"Medicine; Cancer; Drug; Drug delivery; Cancer therapy; Oncology; Intensive care medicine; Pharmacology; Internal medicine; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006856427,0.0001846136,0.0006876187,0.0001784903,0.00008031937,0.000005505756,0.00007254165,0.00008207396,0.0001391503],"category_scores_gemma":[0.0002147591,0.0001306433,0.00007674927,0.0003379545,0.001162919,0.00007084618,0.000008514715,0.000199685,5.854968e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002918886,"about_ca_system_score_gemma":0.0002700932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005452676,"about_ca_topic_score_gemma":0.0001618436,"domain_scores_codex":[0.9981711,0.0001159606,0.0008153885,0.0003998081,0.0002547697,0.0002430094],"domain_scores_gemma":[0.9977586,0.001208077,0.0001840467,0.0001629255,0.0005302484,0.000156078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06003291,0.003179424,0.6037823,0.001028863,0.002457601,0.00007301687,0.005713608,0.00007739078,0.08653134,0.002866404,0.005901499,0.2283557],"study_design_scores_gemma":[0.05644977,0.006131914,0.8806061,0.002322461,0.0003857368,0.00003722227,0.0005166595,0.002869726,0.03167502,0.01455642,0.004077214,0.0003717659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721605,0.008991299,0.0003830713,0.01702773,0.0001114141,0.001045357,0.0000337355,0.00002618618,0.0002206723],"genre_scores_gemma":[0.9947361,0.001735145,0.0003648219,0.002335361,0.0005998434,0.00008627507,0.00003505901,0.00002098195,0.00008637501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2768238,"threshold_uncertainty_score":0.5327481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09298064257482087,"score_gpt":0.4585024538825066,"score_spread":0.3655218113076857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}