{"id":"W2799710201","doi":"10.1186/s40169-018-0185-6","title":"Analyses of repeated failures in cancer therapy for solid tumors: poor tumor‐selective drug delivery, low therapeutic efficacy and unsustainable costs","year":2018,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":486,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Eye Institute; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology; National Cancer Institute; University of Pennsylvania","keywords":"Medicine; Cancer; Drug; Drug delivery; Cancer therapy; Oncology; Intensive care medicine; Pharmacology; Internal medicine; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02075465,0.000723093,0.001131118,0.002278389,0.0006276655,0.00258884,0.001002408,0.00070521,0.004123957],"category_scores_gemma":[0.04094004,0.0002245979,0.001246028,0.002757512,0.00142853,0.001886331,0.001297541,0.00130925,0.0006136125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002850667,"about_ca_system_score_gemma":0.001589203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002494622,"about_ca_topic_score_gemma":0.001954592,"domain_scores_codex":[0.9773722,0.00849458,0.001689024,0.002269185,0.009512368,0.0006625524],"domain_scores_gemma":[0.9314703,0.03164154,0.02334623,0.004894209,0.007771792,0.0008759106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002100731,0.0005312745,0.6864685,0.00200709,0.00254004,0.001004192,0.0009407654,0.008848253,0.004322954,0.01508383,0.009473526,0.2666788],"study_design_scores_gemma":[0.0000685601,0.002170104,0.884618,0.0006308079,0.001966278,0.004145002,0.002307425,0.01487486,0.01285999,0.02907629,0.04708461,0.0001980393],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8233206,0.05810065,0.06940374,0.01157976,0.0006729361,0.001084844,0.008280714,0.0003240488,0.02723279],"genre_scores_gemma":[0.9820127,0.004611649,0.007317103,0.0009952786,0.0002993789,0.0002993508,0.001337753,0.00007859914,0.00304827],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02075465,"threshold_uncertainty_score":0.1097624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09298064257482087,"score_gpt":0.4585024538825066,"score_spread":0.3655218113076857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}