{"id":"W2799809614","doi":"10.1093/nar/gky287","title":"Differences in silencing of mismatched targets by sliced versus diced siRNAs","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canada Excellence Research Chairs, Government of Canada","keywords":"Biology; Gene silencing; Small interfering RNA; Trans-acting siRNA; Genetics; Computational biology; Cell biology; Molecular biology; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007035315,0.0002312519,0.0004294006,0.0003766626,0.000125545,0.000584057,0.000297737,0.000392504,0.001192056],"category_scores_gemma":[0.0008619135,0.0002929137,0.0003941807,0.0001703535,0.0002542618,0.0005189738,0.0004230574,0.0003823378,0.0003936121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253966,"about_ca_system_score_gemma":0.0001520358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414328,"about_ca_topic_score_gemma":0.0002422345,"domain_scores_codex":[0.9992136,0.0001409816,0.0001787161,0.000144443,0.0002397285,0.00008251207],"domain_scores_gemma":[0.9992902,0.0002552329,0.00009395352,0.00006875169,0.0001499713,0.0001418167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005146569,0.000003434108,0.0001249085,0.00002241666,0.000005188321,0.00001850962,0.00001420438,0.00003754897,0.9992064,0.00008049923,0.000004107894,0.0004314153],"study_design_scores_gemma":[0.000008167343,0.0003149797,0.006269335,0.000004995221,0.0000211501,0.0003050996,0.00002941288,0.0009122137,0.9914541,0.0001077118,0.0005652721,0.000007553276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987489,0.002218158,0.007191695,0.00004444933,0.00002695127,0.00003548071,0.0003249771,0.00007437178,0.002594872],"genre_scores_gemma":[0.9931462,0.0006732538,0.004138077,0.00008711699,0.000008034136,0.0000407528,0.0006210135,0.00003562178,0.001249837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192056,"threshold_uncertainty_score":0.003987849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05195090388776134,"score_gpt":0.3428161406845614,"score_spread":0.2908652367968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}