{"id":"W2799889823","doi":"10.1186/s12868-018-0413-4","title":"Haplotype analysis of APOE intragenic SNPs","year":2018,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Haplotype; Apolipoprotein E; Genetics; Single-nucleotide polymorphism; Biology; Locus (genetics); Allele; Population; Gene; Disease; Genotype; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001031848,0.0002299101,0.000406872,0.001434964,0.0004251891,0.0004173979,0.0002300336,0.0002537537,0.003202786],"category_scores_gemma":[0.003105406,0.0001354887,0.0006033881,0.001536741,0.0001433491,0.000161952,0.0004248348,0.0004157525,0.0008681957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767536,"about_ca_system_score_gemma":0.0003973311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002777076,"about_ca_topic_score_gemma":0.004462,"domain_scores_codex":[0.9992793,0.0002117527,0.00006369019,0.0003024049,0.00006260334,0.00008014316],"domain_scores_gemma":[0.9984295,0.0007638498,0.000262248,0.0002193485,0.0002174237,0.0001076362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001165202,0.0001234913,0.8712946,0.0004018956,0.001898327,0.001080902,0.0006683097,0.01142563,0.03608093,0.001390524,0.006039987,0.06843031],"study_design_scores_gemma":[0.0001709284,0.0004250929,0.9227326,0.0001281804,0.001770562,0.001624155,0.0003526995,0.04010835,0.01033168,0.005680262,0.0166021,0.00007357064],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604005,0.0007896779,0.02041103,0.00009030889,0.00003733806,0.00006136172,0.01635808,0.0001459333,0.001705926],"genre_scores_gemma":[0.9753969,0.0001585383,0.007638649,0.00005159275,0.00002100282,0.00006156644,0.01620739,0.00004962284,0.0004147332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202786,"threshold_uncertainty_score":0.01071441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07090312904833271,"score_gpt":0.3670411986810645,"score_spread":0.2961380696327318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}