{"id":"W2799889823","doi":"10.1186/s12868-018-0413-4","title":"Haplotype analysis of APOE intragenic SNPs","year":2018,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Haplotype; Apolipoprotein E; Genetics; Single-nucleotide polymorphism; Biology; Locus (genetics); Allele; Population; Gene; Disease; Genotype; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338399,0.00007608941,0.0001873064,0.0002509739,0.00007692394,0.00001278674,0.00014227,0.00001988693,0.0001700427],"category_scores_gemma":[0.0002718902,0.00005788519,0.0001211151,0.001637246,0.0004577764,0.00007326624,0.00005842551,0.00005008683,0.00007695717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001680941,"about_ca_system_score_gemma":0.0002036124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003112749,"about_ca_topic_score_gemma":0.00002341194,"domain_scores_codex":[0.9988675,0.00004456647,0.0001348563,0.0002869322,0.0004219633,0.0002441957],"domain_scores_gemma":[0.9991832,0.00004821988,0.00004711941,0.0003702161,0.0001101663,0.0002410911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005233575,0.00107926,0.9495703,0.00005082089,0.001975555,0.0001308316,0.0001305323,0.00002267235,0.04301767,0.0005341333,0.0005309447,0.002433924],"study_design_scores_gemma":[0.0004794462,0.0006489124,0.9732866,0.00001023148,0.001517672,0.00000896186,0.00001274855,0.008060806,0.01561233,0.00003589713,0.0002580647,0.00006827858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970046,0.0002669806,0.0006772449,0.00006639269,0.00009119663,0.0001632983,0.00001573391,0.00003209066,0.001682478],"genre_scores_gemma":[0.9992933,0.00002937842,0.0002800052,0.0001887849,0.00003825293,0.000005931026,0.000004370636,0.000006389502,0.0001535482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02740533,"threshold_uncertainty_score":0.236049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07090312904833271,"score_gpt":0.3670411986810645,"score_spread":0.2961380696327318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}