{"id":"W2799893314","doi":"10.1021/acs.jmedchem.7b01906","title":"Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-P<sub>α,α</sub>-Dithiophosphate Analogues","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Chemistry; Pyrophosphatase; Uridine; Biochemistry; Stereochemistry; Enzyme; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146593,0.000470026,0.0004165374,0.0001433879,0.00008292789,0.0002260659,0.0003182052,0.0002955962,0.0006352267],"category_scores_gemma":[0.0001228084,0.0001795711,0.0001985833,0.0001492474,0.0001515937,0.0001895534,0.0001642555,0.0007767851,0.0002981929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000246744,"about_ca_system_score_gemma":0.0001243264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441474,"about_ca_topic_score_gemma":0.0007540826,"domain_scores_codex":[0.9999037,0.00001721206,0.00000863517,0.00002745131,0.00002127131,0.000021791],"domain_scores_gemma":[0.9999573,0.00001033254,0.0000112744,0.000003963505,0.000006476988,0.00001065643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002466346,0.00007677035,0.00008701785,0.0001858951,0.00001504142,0.0001263987,0.00002436221,0.0009161836,0.9889752,0.0002849178,0.0001438928,0.008917755],"study_design_scores_gemma":[0.00007726466,0.001000585,0.000683391,0.00001057876,0.00002762966,0.000443333,0.000008137254,0.001151174,0.9890543,0.00004726343,0.007485457,0.00001088916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429235,0.02710635,0.02042031,0.0001709767,0.0001201322,0.0002479699,0.0007328418,0.000247933,0.008029963],"genre_scores_gemma":[0.9763264,0.008217584,0.01066619,0.0001100252,0.00002538131,0.0001446896,0.0008118225,0.00002472181,0.003673268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006352267,"threshold_uncertainty_score":0.002125084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004924405440390825,"score_gpt":0.2164091379403143,"score_spread":0.2114847324999235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}