{"id":"W2799942610","doi":"10.1016/j.ebiom.2018.04.019","title":"Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University Health Network; Princess Margaret Cancer Centre; Genome British Columbia","funders":"Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Taiwan Forestry Research Institute; National Institute for Health and Care Research; Public Health Agency; Prostate Cancer UK; Academy of Medical Sciences; Cancer Research UK; University of Manchester; Prostate Cancer Canada; Medical Research Council; Terry Fox Research Institute; Movember Foundation","keywords":"Prostate cancer; Medicine; Radiation therapy; Oncology; Carbogen; Prostatectomy; Gene signature; Internal medicine; Proportional hazards model; Metastasis; Bladder cancer; Cancer; Prostate; Gene expression; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976392,0.0001309786,0.0001965119,0.00006066774,0.00005698586,0.000005219029,0.00006287875,0.0001264443,0.00003351418],"category_scores_gemma":[0.00008459692,0.0001056206,0.00003056919,0.0001342418,0.0002013466,0.000003070125,0.00003848652,0.00004230925,0.000001093498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121833,"about_ca_system_score_gemma":0.0001677695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001886411,"about_ca_topic_score_gemma":0.00002684063,"domain_scores_codex":[0.9991468,0.00001573961,0.000257845,0.0002715676,0.0001196882,0.000188323],"domain_scores_gemma":[0.9994419,0.00001067638,0.0001217028,0.0001387564,0.0002090951,0.00007793162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002652014,0.00003896483,0.0002692535,0.0000746794,0.0001026051,2.788313e-7,0.0004736558,0.000002397873,0.9534104,0.00001263695,0.004438864,0.040911],"study_design_scores_gemma":[0.002050026,0.0003162299,0.0009488686,0.00005759575,0.00006541063,0.00000536016,0.00004596088,0.00002156729,0.674692,0.0000483192,0.3216361,0.0001125211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856176,0.01123299,0.00113531,0.0003092959,0.0008719453,0.0006629555,0.00005923802,0.0000118636,0.00009875255],"genre_scores_gemma":[0.9903836,0.0008817888,0.004261692,0.0002430548,0.001253612,0.0001728161,0.0006114489,0.00002785826,0.002164088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3171972,"threshold_uncertainty_score":0.4307085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009180528513499361,"score_gpt":0.2619656832072685,"score_spread":0.2527851546937691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}