{"id":"W2799942610","doi":"10.1016/j.ebiom.2018.04.019","title":"Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University Health Network; Princess Margaret Cancer Centre; Genome British Columbia","funders":"Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Taiwan Forestry Research Institute; National Institute for Health and Care Research; Public Health Agency; Prostate Cancer UK; Academy of Medical Sciences; Cancer Research UK; University of Manchester; Prostate Cancer Canada; Medical Research Council; Terry Fox Research Institute; Movember Foundation","keywords":"Prostate cancer; Medicine; Radiation therapy; Oncology; Carbogen; Prostatectomy; Gene signature; Internal medicine; Proportional hazards model; Metastasis; Bladder cancer; Cancer; Prostate; Gene expression; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006160438,0.0002295349,0.0004086841,0.0004949239,0.0001383546,0.000323417,0.0002292207,0.000164488,0.0005417229],"category_scores_gemma":[0.0009872759,0.00008711353,0.0002151545,0.0003041188,0.0002284675,0.0001100988,0.0002726151,0.0003430862,0.0001612446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003255289,"about_ca_system_score_gemma":0.000661635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005323018,"about_ca_topic_score_gemma":0.0008145249,"domain_scores_codex":[0.9997268,0.00007072296,0.00001554751,0.00005709171,0.00009919893,0.00003071973],"domain_scores_gemma":[0.9992617,0.0001491534,0.000238652,0.00005119503,0.0001822593,0.0001170782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002886727,0.0004171837,0.3234268,0.000355907,0.0002359637,0.0002016632,0.000125304,0.0042878,0.579616,0.0002023623,0.0007769261,0.08746747],"study_design_scores_gemma":[0.0004554873,0.00930547,0.661182,0.000103572,0.0007026023,0.002625915,0.0002050487,0.02698434,0.2913775,0.0006612327,0.006316258,0.00008050264],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934161,0.000620541,0.004794964,0.00008876747,0.00001062629,0.0001081832,0.0005711798,0.00004031571,0.0003492521],"genre_scores_gemma":[0.9869902,0.0001856804,0.0108734,0.00006224061,0.00001312313,0.00009988481,0.001519845,0.000009302517,0.0002464243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006160438,"threshold_uncertainty_score":0.00325799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009180528513499361,"score_gpt":0.2619656832072685,"score_spread":0.2527851546937691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}