{"id":"W2799964288","doi":"10.1161/circgen.116.001663","title":"Common Coding Variants in <i>SCN10A</i> Are Associated With the Nav1.8 Late Current and Cardiac Conduction","year":2018,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Stephen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Georgia Clinical and Translational Science Alliance; National Institutes of Health; Cleveland Clinic; Fondation Leducq; National Center for Research Resources; American Heart Association","keywords":"Missense mutation; Linkage disequilibrium; Genetics; Locus (genetics); Haplotype; Biology; Single-nucleotide polymorphism; QRS complex; Genotype; Gene; Internal medicine; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003667853,0.0008685386,0.0004377997,0.000669428,0.0003367024,0.0003161957,0.0004552139,0.0007352504,0.00403072],"category_scores_gemma":[0.001099862,0.000178686,0.0005155405,0.0008337874,0.0005197577,0.0001541783,0.0002942115,0.0004494868,0.0004169338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001920414,"about_ca_system_score_gemma":0.000194407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002636635,"about_ca_topic_score_gemma":0.003292651,"domain_scores_codex":[0.9996166,0.00005732196,0.00006537963,0.000153639,0.00005793424,0.00004907404],"domain_scores_gemma":[0.9984393,0.0003738721,0.0008733379,0.00006690156,0.00007428364,0.0001723558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00247982,0.0001468448,0.8505778,0.0002107285,0.0009801995,0.008120302,0.0004029185,0.0007323332,0.1224884,0.0004753854,0.001551314,0.01183398],"study_design_scores_gemma":[0.0001147024,0.000319036,0.9806625,0.00006702477,0.0004856877,0.0110099,0.0001417343,0.001135346,0.004245329,0.0004516268,0.001339306,0.00002787527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969497,0.0004581701,0.0009698814,0.0001414658,0.00003746106,0.00001857607,0.0007189667,0.00003886851,0.0006669299],"genre_scores_gemma":[0.9985702,0.0001256185,0.0005255346,0.00007976608,0.00003557148,0.000009393404,0.0004160405,0.00001422988,0.0002235905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00403072,"threshold_uncertainty_score":0.01348412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301122222029441,"score_gpt":0.2763492873324082,"score_spread":0.2533380651121138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}