{"id":"W2799973353","doi":"10.1016/j.bbi.2018.04.017","title":"White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: Combined DTI and immunological investigation in the different phases of bipolar disorder","year":2018,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre; University of Ottawa","funders":"Materials Research Institute, Pennsylvania State University; Università degli Studi di Genova","keywords":"CD8; Fractional anisotropy; White matter; T cell; Immunology; Effector; Biology; Chemistry; Pathology; Medicine; Antigen; Immune system; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459354,0.000182151,0.0002349008,0.00009589489,0.0001288937,0.00003932275,0.0000888059,0.00009844488,0.00004510715],"category_scores_gemma":[0.00001195194,0.00009332845,0.00002738431,0.0002022999,0.000304183,0.00006390213,0.00003441008,0.0003518629,5.140518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001853859,"about_ca_system_score_gemma":0.00001537459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000795964,"about_ca_topic_score_gemma":0.003431487,"domain_scores_codex":[0.998894,0.0004332075,0.0002374853,0.0001652997,0.0001128859,0.0001570806],"domain_scores_gemma":[0.9995626,0.00008850856,0.00006544015,0.0002279184,0.00003158143,0.00002401572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002619094,0.001204561,0.9418754,0.00003303588,0.00001278446,0.000007690153,0.007375366,1.562743e-7,0.04880689,0.000004727586,0.000003993062,0.0004134988],"study_design_scores_gemma":[0.005329593,0.001721403,0.9902053,0.00008886682,0.0001616662,0.00009805792,0.001137241,0.00002648415,0.001102606,0.00002183875,0.000006966831,0.00009993352],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974689,0.001123238,0.000008878076,0.0004365318,0.00002427373,0.0008994223,0.00001921951,0.000007088327,0.00001244664],"genre_scores_gemma":[0.9993987,0.00008154612,0.00002603736,0.0001421164,0.000006481693,0.00008171904,0.0002318436,0.00000990933,0.00002165391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04832995,"threshold_uncertainty_score":0.3805824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00932538442031184,"score_gpt":0.2356757082413901,"score_spread":0.2263503238210783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}