{"id":"W2800005762","doi":"10.3389/fncel.2018.00124","title":"Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability","year":2018,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; British Columbia Knowledge Development Fund; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Microtubule; Probenecid; Pannexin; Cell biology; Chemistry; Neurite; Microtubule polymerization; Microtubule-associated protein; Tubulin; Proximity ligation assay; Biology; Pharmacology; Biochemistry; In vitro; Receptor; Intracellular; Gap junction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006874197,0.0001798772,0.0001767632,0.0001117521,0.0001352245,0.00004476938,0.000254636,0.0001335592,0.00000951178],"category_scores_gemma":[0.0008660408,0.000168366,0.00004247925,0.0002386938,0.0006802579,0.00001634772,0.0002280422,0.0001245245,0.000001883068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003420681,"about_ca_system_score_gemma":0.0001299127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005810452,"about_ca_topic_score_gemma":0.00009057298,"domain_scores_codex":[0.99828,0.0002600853,0.0002483234,0.0007468359,0.0001204353,0.0003443318],"domain_scores_gemma":[0.9993046,0.00002131594,0.00009601495,0.0003943222,0.00006725418,0.0001164935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001027537,0.0001451275,0.01481054,0.00001173641,0.000002155043,0.000007309131,0.00008090177,0.000001175246,0.9829153,0.000008421346,0.0002685444,0.0007212298],"study_design_scores_gemma":[0.0006128245,0.0009140624,0.0146833,0.00002073266,0.000004711399,0.00002455474,0.0002140077,0.0007666606,0.9480343,0.00004348473,0.03444278,0.0002385961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992193,0.0002984636,0.006030526,0.0002069689,0.0006784731,0.0005013386,0.00003265029,0.00001459792,0.00004399748],"genre_scores_gemma":[0.9969355,0.00003259792,0.002408349,0.0002287566,0.0001301914,0.00005157446,0.00001248495,0.00001579326,0.0001847116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03488105,"threshold_uncertainty_score":0.6865767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428051637984226,"score_gpt":0.2435756734444256,"score_spread":0.2292951570645833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}