{"id":"W2800035423","doi":"10.1097/pas.0000000000001072","title":"Routine Use of Adjunctive p16 Immunohistochemistry Improves Diagnostic Agreement of Cervical Biopsy Interpretation","year":2018,"lang":"en","type":"article","venue":"The American Journal of Surgical Pathology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Blinding; H&E stain; Biopsy; Immunohistochemistry; Medical diagnosis; Cervical intraepithelial neoplasia; Diagnostic accuracy; Squamous intraepithelial lesion; Pathology; Radiology; Internal medicine; Randomized controlled trial; Cervical cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03324778,0.0005929006,0.001025456,0.001283681,0.000438098,0.001380329,0.0009503848,0.000828651,0.0005920175],"category_scores_gemma":[0.1101867,0.0005108353,0.001145873,0.0008006583,0.0009782284,0.0009160413,0.001442372,0.001086692,0.0003294198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000647784,"about_ca_system_score_gemma":0.0007607149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001648898,"about_ca_topic_score_gemma":0.002592144,"domain_scores_codex":[0.938324,0.03931998,0.003240392,0.007682974,0.01074699,0.0006856847],"domain_scores_gemma":[0.8456699,0.113943,0.01724371,0.01291167,0.008744359,0.001487319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005423249,0.0002364065,0.9149862,0.0002195461,0.002109224,0.0001188989,0.0005851868,0.001614117,0.007697552,0.00008341807,0.000397456,0.06652878],"study_design_scores_gemma":[0.0001090135,0.003602446,0.9794519,0.00006931622,0.001028615,0.0006460566,0.000159184,0.007066072,0.006772611,0.0002455543,0.0008086197,0.0000406761],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863191,0.004002031,0.007567824,0.0002333972,0.00006593877,0.00008912347,0.0001732398,0.0001228125,0.001426631],"genre_scores_gemma":[0.9954862,0.0002709777,0.003855895,0.00007013316,0.00004435163,0.00001856771,0.0001338927,0.00001582423,0.0001040187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03324778,"threshold_uncertainty_score":0.1758332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072004607551232,"score_gpt":0.3302548097327196,"score_spread":0.3095347636572073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}