{"id":"W2800067592","doi":"10.1007/s10637-018-0599-4","title":"A multicentre, open-label phase II study of Irinotecan, capecitabine (Xeloda®), and Oxaliplatin (IXO) as first-line treatment in patients with metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma","year":2018,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Ottawa Hospital; University of Alberta; St. Michael's Hospital","funders":"Sanofi; Roche","keywords":"Medicine; Internal medicine; Gastroenterology; Irinotecan; Capecitabine; Phases of clinical research; Neutropenia; Oxaliplatin; Nausea; Febrile neutropenia; Clinical endpoint; Toxicity; Cancer; Surgery; Clinical trial; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437387,0.0003175403,0.0005357716,0.0003743785,0.0001535481,0.00003875882,0.0001385466,0.00003490153,0.0002919314],"category_scores_gemma":[0.0001295129,0.000228572,0.00002659117,0.0007514695,0.0001627188,0.0002801726,0.0001489159,0.0001120371,0.00001182487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832971,"about_ca_system_score_gemma":0.0004035749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00340207,"about_ca_topic_score_gemma":0.002339108,"domain_scores_codex":[0.997925,0.00006217112,0.0006067935,0.0004877801,0.0006069871,0.0003112556],"domain_scores_gemma":[0.9987984,0.0001125497,0.0003009677,0.0002781727,0.0002051784,0.0003046757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009500278,0.0138401,0.9480423,0.0001075726,0.0005102764,0.00009118307,0.006568597,0.0001100925,0.00003769584,0.00008413858,0.001208727,0.01989903],"study_design_scores_gemma":[0.1374899,0.04617886,0.8123605,0.0001548208,0.0006716262,0.00001724795,0.001024832,0.001385352,0.0001028872,0.0001139596,0.0002954117,0.0002045044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958887,0.00005742212,0.00006950756,0.0009339566,0.00009742872,0.002779066,0.00002582815,0.00002596084,0.0001221988],"genre_scores_gemma":[0.9909522,0.000007422153,0.005769306,0.0003678759,0.0001481326,0.0001020167,0.0001722151,0.0000301103,0.002450718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1356817,"threshold_uncertainty_score":0.9320896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04650012193401043,"score_gpt":0.3167996461221093,"score_spread":0.2702995241880988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}