{"id":"W2800074119","doi":"10.1038/s41556-018-0089-0","title":"TFAP2C regulates transcription in human naive pluripotency by opening enhancers","year":2018,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Jane Coffin Childs Memorial Fund for Medical Research; Howard Hughes Medical Institute","keywords":"Enhancer; Epiblast; Biology; Induced pluripotent stem cell; Transcription factor; Embryonic stem cell; Cell biology; Chromatin; SOX2; Genetics; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320225,0.0002237337,0.0002203601,0.0001241562,0.0001332534,0.00001904883,0.0004421976,0.001003626,0.0001421307],"category_scores_gemma":[0.0000449941,0.0002087678,0.00008556212,0.0001968349,0.0003015698,0.000007225883,0.0001199038,0.0005308246,0.00004153399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005022636,"about_ca_system_score_gemma":0.00005898224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008027649,"about_ca_topic_score_gemma":0.0001387329,"domain_scores_codex":[0.9981707,0.0001955565,0.0002735271,0.0006923191,0.00011925,0.0005486633],"domain_scores_gemma":[0.9993235,0.00001537699,0.00008264208,0.0003605604,0.0001249299,0.00009297926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136583,0.00005401958,0.001035496,0.00001813861,0.00001834489,0.000003612156,0.00006748243,0.000003134179,0.9920376,0.00005762898,0.00565636,0.000934548],"study_design_scores_gemma":[0.000759402,0.0006059122,0.0004997741,0.0000145738,0.000006057745,0.000004422612,0.00004241639,0.00003056948,0.9109209,0.0001838059,0.08670676,0.0002254611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819406,0.004761157,0.0002060332,0.0002290768,0.0003532762,0.0003200902,0.00003314955,0.00001925213,0.0121374],"genre_scores_gemma":[0.9945825,0.0003500035,0.0002582235,0.0003280633,0.0003356149,0.00002685185,0.0006226848,0.00002848786,0.00346752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08111674,"threshold_uncertainty_score":0.8513303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006756461231206254,"score_gpt":0.279161600113168,"score_spread":0.2724051388819617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}