{"id":"W2800074119","doi":"10.1038/s41556-018-0089-0","title":"TFAP2C regulates transcription in human naive pluripotency by opening enhancers","year":2018,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":211,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Health and Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Jane Coffin Childs Memorial Fund for Medical Research; Howard Hughes Medical Institute","keywords":"Enhancer; Epiblast; Biology; Induced pluripotent stem cell; Transcription factor; Embryonic stem cell; Cell biology; Chromatin; SOX2; Genetics; Gastrulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815416,0.0003075102,0.0002289022,0.0003566664,0.0004247769,0.000988708,0.0003443714,0.0003993397,0.003566906],"category_scores_gemma":[0.0004168687,0.0002999942,0.0003797946,0.0002030245,0.000567459,0.0004047727,0.0004583227,0.0008261773,0.001267436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000679095,"about_ca_system_score_gemma":0.00034134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188158,"about_ca_topic_score_gemma":0.00198448,"domain_scores_codex":[0.9996448,0.00003301978,0.00002023111,0.0001244659,0.00008337286,0.0000941266],"domain_scores_gemma":[0.9997213,0.00008172679,0.00002856804,0.00005351622,0.00004641644,0.00006838193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013027,0.00002532224,0.0006641479,0.00002551683,0.000005293695,0.0000817808,0.00003062247,0.00008636505,0.9944323,0.0006893366,0.0002506668,0.0035074],"study_design_scores_gemma":[0.00003813166,0.00004998245,0.007466671,0.000009228311,0.00001089498,0.0003176358,0.00005172924,0.001162018,0.9853123,0.0005208397,0.005051085,0.000009440102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703307,0.002151805,0.01586566,0.0003666973,0.0002003973,0.00004636803,0.001516201,0.0006423927,0.008879814],"genre_scores_gemma":[0.9904694,0.0002597172,0.00330785,0.0001400228,0.00003759648,0.00002889026,0.001156354,0.0001995901,0.004400583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003566906,"threshold_uncertainty_score":0.01193255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006756461231206254,"score_gpt":0.279161600113168,"score_spread":0.2724051388819617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}