{"id":"W2800153285","doi":"10.1016/j.jgg.2018.02.009","title":"Functional non-homologous end joining patterns triggered by CRISPR/Cas9 in human cells","year":2018,"lang":"en","type":"letter","venue":"Journal of genetics and genomics/Journal of Genetics and Genomics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; National Natural Science Foundation of China; Eye Hospital Wenzhou Medical University; Wenzhou Medical University","keywords":"CRISPR; Cas9; Genome editing; Computational biology; Biology; Human genome; Mutagenesis; Genome engineering; Palindrome; Cleavage (geology); DNA; Genetics; Genome; Molecular biology; Cell biology; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009057908,0.0002551268,0.0004322417,0.0001483627,0.0004628709,0.0009259048,0.0004486732,0.005024696,0.002452963],"category_scores_gemma":[0.002323369,0.0001472674,0.0004309622,0.00009779735,0.0005780642,0.0003412871,0.0003043378,0.003644265,0.001391383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007855652,"about_ca_system_score_gemma":0.0002882132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004842036,"about_ca_topic_score_gemma":0.0005512962,"domain_scores_codex":[0.9993879,0.0002015046,0.00006930622,0.00006877867,0.0001732597,0.00009924201],"domain_scores_gemma":[0.9990257,0.0005950267,0.00007394802,0.0001101338,0.0001009786,0.00009423101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002787051,0.000327987,0.004327473,0.0004827422,0.00009864271,0.07706241,0.0004719901,0.001203445,0.1881779,0.03303308,0.5880747,0.1039526],"study_design_scores_gemma":[0.0004779399,0.0007041651,0.003007934,0.00008982117,0.0001029701,0.03699609,0.0002807414,0.004691829,0.1863682,0.01467696,0.7525425,0.00006091066],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1143579,0.01451969,0.01938304,0.7426087,0.05859645,0.0001730966,0.001058009,0.00141459,0.0478884],"genre_scores_gemma":[0.723756,0.008007481,0.008378038,0.1788251,0.01404005,0.0002589534,0.0007397197,0.0001768601,0.06581789],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005024696,"threshold_uncertainty_score":0.00820601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009713587251680304,"score_gpt":0.2554168450005035,"score_spread":0.2457032577488232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}