{"id":"W2800164512","doi":"10.1016/j.jaci.2018.03.011","title":"A novel human mast cell activation test for peanut allergy","year":2018,"lang":"en","type":"letter","venue":"Journal of Allergy and Clinical Immunology","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Army Medical Research and Development Command; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Medical Research Council; Alberta Heritage Foundation for Medical Research; King's College London; European Academy of Allergy and Clinical Immunology; University of Alberta; Genome Prairie; National Peanut Board; National Institute for Health and Care Research; Genome Canada; Immune Tolerance Network; Sanofi; Menzies Centre for Australian Studies, King's College London, University of London; AstraZeneca; Asthma and Lung UK; Natural Sciences and Engineering Research Council of Canada; King's College Hospital NHS Foundation Trust; Pfizer","keywords":"Overdiagnosis; Peanut allergy; Anaphylaxis; Immunoglobulin E; Medicine; Food allergy; Gold standard (test); Allergy; Immunology; Oral immunotherapy; Oral food challenge; Mast cell; Oral allergy syndrome; Internal medicine; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000619075,0.0005721137,0.0005797169,0.000995856,0.0001540271,0.0004248117,0.0006280793,0.001022495,0.008185657],"category_scores_gemma":[0.001217781,0.0001561904,0.000533483,0.0004243867,0.0001919755,0.0005349304,0.0003882803,0.0009048976,0.002737215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240786,"about_ca_system_score_gemma":0.0002132402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003635883,"about_ca_topic_score_gemma":0.0004340008,"domain_scores_codex":[0.9990452,0.0002209946,0.00004491486,0.0002052446,0.0004103673,0.00007323927],"domain_scores_gemma":[0.9996548,0.0001425878,0.00005260074,0.00002663183,0.00009572817,0.00002781871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003831144,0.0007316073,0.03278113,0.001876147,0.0002350154,0.00313064,0.0001429685,0.0005109562,0.5990259,0.001227133,0.0165459,0.3399616],"study_design_scores_gemma":[0.001718378,0.01588935,0.1892085,0.001086021,0.001181685,0.07407713,0.0002961359,0.03415211,0.4703639,0.002743642,0.2089716,0.0003115353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6063876,0.1336401,0.1492276,0.006435642,0.007711778,0.004877463,0.01256817,0.00556197,0.07358964],"genre_scores_gemma":[0.883745,0.01187822,0.07264983,0.003127823,0.0009988892,0.001183839,0.004172231,0.00009997622,0.02214416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008185657,"threshold_uncertainty_score":0.02738374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06331845406068977,"score_gpt":0.3680004396001583,"score_spread":0.3046819855394686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}