{"id":"W2800244745","doi":"10.1016/j.ymgmr.2018.04.005","title":"Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine","year":2018,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism Reports","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"British Columbia Children's Hospital","funders":"Rare Disease Foundation","keywords":"Trimethylamine N-oxide; Carnitine; Internal medicine; Interquartile range; Medicine; Gastroenterology; Endocrinology; Metabolite; Chemistry; Trimethylamine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002325627,0.0003968455,0.0004284132,0.0002457778,0.00006007447,0.00004756502,0.0001231871,0.0002045476,0.00001476062],"category_scores_gemma":[0.00008624815,0.0003307927,0.00005777841,0.0004334236,0.0002254954,0.00001023046,0.00008735777,0.0001288408,0.000001211531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006105738,"about_ca_system_score_gemma":0.0001157664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002129765,"about_ca_topic_score_gemma":0.0009358301,"domain_scores_codex":[0.9976075,0.0001534814,0.0005454581,0.0008336921,0.000363593,0.0004962165],"domain_scores_gemma":[0.9988541,0.000008328117,0.00023826,0.0005636501,0.0001888254,0.0001468593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002042428,0.0006304737,0.8353571,0.00003288711,0.0001969291,0.0001116158,0.0001455838,0.0005003525,0.13357,0.00006098541,0.000129555,0.02722203],"study_design_scores_gemma":[0.00700182,0.0005719151,0.912497,0.00002638523,0.0001211242,0.00001865622,0.00004527225,0.00009374249,0.06212968,0.000135324,0.01677852,0.0005805157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960024,0.001375332,0.0009270667,0.00003473826,0.0001456017,0.0008093518,0.00001128478,0.00001175198,0.0006824183],"genre_scores_gemma":[0.9945645,0.0003262235,0.004310158,0.0001210828,0.00007837194,0.00007104713,0.0003004436,0.0000676576,0.0001605181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07713993,"threshold_uncertainty_score":0.9999144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002622816583466528,"score_gpt":0.1972107639065288,"score_spread":0.1945879473230623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}