{"id":"W2800306828","doi":"10.2147/cmar.s162714","title":"Is progression-free survival a more relevant endpoint than overall survival in first-line HR+/HER2− metastatic breast cancer?","year":2018,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"European Society for Medical Oncology","keywords":"Medicine; Metastatic breast cancer; Internal medicine; Oncology; Progression-free survival; Hazard ratio; Clinical endpoint; Breast cancer; Cancer; Observational study; Randomized controlled trial; Quality of life (healthcare); Chemotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001400221,0.0004000786,0.0006534759,0.0005814801,0.0003296781,0.00009273484,0.000488827,0.00009849328,0.001513237],"category_scores_gemma":[0.00005737586,0.0003083111,0.0001088058,0.0009923371,0.0008813149,0.0002359453,0.0007922411,0.0006457207,0.00003632068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000683955,"about_ca_system_score_gemma":0.0002237395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002654105,"about_ca_topic_score_gemma":0.006642051,"domain_scores_codex":[0.9954284,0.0002040731,0.0004940477,0.0009585764,0.001733423,0.001181418],"domain_scores_gemma":[0.9978943,0.0001637581,0.000123492,0.0009840584,0.0004765349,0.0003578829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01897844,0.001681683,0.2607787,0.006371411,0.002584489,0.001112292,0.01081045,0.0001133321,0.001177637,0.003183018,0.0183451,0.6748634],"study_design_scores_gemma":[0.01748815,0.0009268698,0.6985187,0.004339033,0.0003071595,0.00006545831,0.003243999,0.001265246,0.0008961385,0.006130993,0.2658046,0.00101371],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8922926,0.01732552,0.0007553491,0.0771761,0.001450489,0.004619196,0.0006359024,0.0002281594,0.005516742],"genre_scores_gemma":[0.9539613,0.01548789,0.002569286,0.0008089445,0.00171231,0.00162896,0.00006112376,0.0001738062,0.02359646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6738497,"threshold_uncertainty_score":0.9999369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09342696169412701,"score_gpt":0.4293813592579829,"score_spread":0.3359543975638559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}