{"id":"W2800319258","doi":"10.1016/j.exphem.2018.04.008","title":"RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"RUNX1; Biology; Transcription factor; Core binding factor; Context (archaeology); Cell growth; Neuroblastoma RAS viral oncogene homolog; Leukemia; Cancer research; Cell culture; Gene; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001537278,0.0002872545,0.0005990741,0.0002790462,0.0001045985,0.00001020631,0.0002197787,0.0002789721,0.001002748],"category_scores_gemma":[0.00001981828,0.0002718394,0.0001112971,0.0002944803,0.0006534592,0.0001333694,0.00008833742,0.0001605297,0.0001019829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001052551,"about_ca_system_score_gemma":0.0004765567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001933324,"about_ca_topic_score_gemma":0.000005862676,"domain_scores_codex":[0.9977233,0.0001090796,0.0006377024,0.0005119905,0.0004788739,0.0005390071],"domain_scores_gemma":[0.9991427,0.00008978119,0.0001563851,0.0002833385,0.0001456726,0.0001821145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005626661,0.000825888,0.003756701,0.0001836753,0.00004849955,0.00006073993,0.00120812,0.00000150655,0.9838421,0.005250562,0.004245617,0.00001389628],"study_design_scores_gemma":[0.006735088,0.001341886,0.001249689,0.00007457968,0.00003511725,0.0003633345,0.0003106197,0.001777416,0.9873017,0.0003655161,0.0002346366,0.000210392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904445,0.002493396,0.0008654952,0.0001381758,0.0001603132,0.0006286409,0.00003527114,0.00005725924,0.005176881],"genre_scores_gemma":[0.9948696,0.0000144619,0.003403051,0.0001141368,0.0001160735,0.00009118427,0.000228031,0.00005451297,0.00110898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006172422,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136447582778079,"score_gpt":0.2823087513159802,"score_spread":0.2709442754881994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}