{"id":"W2800342506","doi":"10.1039/c8ob00704g","title":"Manipulation of a DNA aptamer–protein binding site through arylation of internal guanine residues","year":2018,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lethbridge College; University of Lethbridge; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Chemistry; Aptamer; Nucleobase; Guanine; Thrombin; Aryl; Stereochemistry; DNA; G-quadruplex; Antiparallel (mathematics); Combinatorial chemistry; Biochemistry; Nucleotide; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153428,0.0002775307,0.0001850881,0.00006682509,0.00007447302,0.0001596645,0.0001847476,0.0002498366,0.000732606],"category_scores_gemma":[0.0002022974,0.00009205961,0.0001354314,0.0001015561,0.0002145647,0.0001573893,0.000160504,0.0003800481,0.0002907296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145233,"about_ca_system_score_gemma":0.0001104875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003453365,"about_ca_topic_score_gemma":0.0005306216,"domain_scores_codex":[0.999927,0.00001554369,0.000004848793,0.00002270719,0.00001767057,0.00001215046],"domain_scores_gemma":[0.9998871,0.00002987576,0.00004708353,0.0000146695,0.000009230027,0.00001203823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000214078,0.000006209933,0.00009412732,0.00001955236,0.000002608023,0.0000267128,0.000007273467,0.0001159605,0.9984205,0.000145553,0.000005734503,0.001134331],"study_design_scores_gemma":[0.00000627406,0.0001469631,0.0005745786,0.000001815175,0.000005027478,0.00009693994,0.000006499572,0.0006638785,0.9973115,0.00005051843,0.001132748,0.000003388526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862445,0.0006406161,0.01184721,0.00005487361,0.00002154672,0.00002094723,0.00005584032,0.00008657886,0.001027943],"genre_scores_gemma":[0.9924064,0.0003372664,0.006390211,0.00003799994,0.000004736235,0.00001724795,0.00004645343,0.00001478493,0.0007448159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000732606,"threshold_uncertainty_score":0.002450764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00863176910634701,"score_gpt":0.2601543390455417,"score_spread":0.2515225699391947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}