{"id":"W2800374489","doi":"10.1093/hmg/ddy140","title":"A plausibly causal functional lupus-associated risk variant in the STAT1–STAT4 locus","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China; Lupus Research Alliance; National Key Research and Development Program of China; U.S. Department of Veterans Affairs","keywords":"Biology; Locus (genetics); Allele; Genetics; Systemic lupus erythematosus; Expression quantitative trait loci; Genotype; Immunology; Disease; Gene; Single-nucleotide polymorphism; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003271264,0.0004690639,0.0004019827,0.0005161313,0.0003120813,0.0002864431,0.0003419562,0.0007252055,0.004217374],"category_scores_gemma":[0.001179855,0.0001418439,0.0005997099,0.0004731202,0.0003692123,0.0001140586,0.0002778852,0.0005300326,0.0003081717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979802,"about_ca_system_score_gemma":0.0001764336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009733954,"about_ca_topic_score_gemma":0.001237753,"domain_scores_codex":[0.9996699,0.00008348045,0.00002732674,0.0001168243,0.0000569024,0.00004560683],"domain_scores_gemma":[0.999424,0.0002973409,0.0001544841,0.00004624549,0.0000181699,0.00005974135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004265722,0.0002444027,0.3393956,0.0003037026,0.0007882384,0.01138686,0.0004470359,0.002887221,0.6044957,0.003157845,0.0007942652,0.03183344],"study_design_scores_gemma":[0.001156516,0.001392922,0.8605174,0.0001370341,0.001774522,0.02811702,0.0002484356,0.01564663,0.07418798,0.009400173,0.007299637,0.000121652],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942626,0.0003896021,0.00389152,0.0001668806,0.00002257662,0.00001545448,0.0006670243,0.00007931201,0.0005049531],"genre_scores_gemma":[0.9985146,0.00004708446,0.0009284125,0.00005387932,0.00001435416,0.000007075495,0.0002747962,0.000009486577,0.0001503885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004217374,"threshold_uncertainty_score":0.01410854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114340379892081,"score_gpt":0.3074986497155841,"score_spread":0.2763552459166633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}