{"id":"W2800374489","doi":"10.1093/hmg/ddy140","title":"A plausibly causal functional lupus-associated risk variant in the STAT1–STAT4 locus","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China; Lupus Research Alliance; National Key Research and Development Program of China; U.S. Department of Veterans Affairs","keywords":"Biology; Locus (genetics); Allele; Genetics; Systemic lupus erythematosus; Expression quantitative trait loci; Genotype; Immunology; Disease; Gene; Single-nucleotide polymorphism; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001078612,0.0002297501,0.0003077223,0.0002281019,0.0002237257,0.00006489926,0.0002763146,0.0001717078,0.0003310437],"category_scores_gemma":[0.0002996451,0.0001732524,0.0001075531,0.0004972136,0.0002607728,0.00002207589,0.0001146549,0.0004816003,0.0002331825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886507,"about_ca_system_score_gemma":0.0004013392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071431,"about_ca_topic_score_gemma":0.00065141,"domain_scores_codex":[0.996933,0.0005146105,0.0004508558,0.0004090751,0.001113325,0.0005791337],"domain_scores_gemma":[0.9984998,0.0001296316,0.0001419561,0.0007555428,0.0003240924,0.000149033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001067813,0.002757068,0.6513607,0.000552139,0.00169171,0.01201251,0.03408534,0.0003216827,0.2273069,0.008250378,0.0586906,0.001903198],"study_design_scores_gemma":[0.04250761,0.01065088,0.788987,0.001948323,0.001726605,0.04846162,0.01126996,0.0106818,0.01535715,0.02093308,0.04464301,0.002832983],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914721,0.000693591,0.002607691,0.0002079047,0.0002820056,0.0007804603,0.00002865167,0.00004627587,0.003881362],"genre_scores_gemma":[0.9976599,0.00005557383,0.0003558494,0.0004651822,0.0002672925,0.00005488149,0.00007724938,0.00005971278,0.001004361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2119497,"threshold_uncertainty_score":0.7065029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114340379892081,"score_gpt":0.3074986497155841,"score_spread":0.2763552459166633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}