{"id":"W2800408217","doi":"10.20944/preprints201805.0081.v1","title":"Population-Based Screening for Severe Combined Immunodeficiency in Manitoba, Canada","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Population; Mutation; Severe combined immunodeficiency; Founder effect; Genotype; Newborn screening; Incidence (geometry); Immunodeficiency; High Resolution Melt; DNA; Biology; Genetics; Virology; Medicine; Haplotype; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005795366,0.000444956,0.0003209637,0.002599526,0.002287488,0.0008345108,0.001095169,0.0003071197,0.002185742],"category_scores_gemma":[0.001474346,0.000304629,0.0002706987,0.004568039,0.000727688,0.0002082571,0.0005939085,0.0004123191,0.0003428929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02287576,"about_ca_system_score_gemma":0.03501709,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9956118,"about_ca_topic_score_gemma":0.997339,"domain_scores_codex":[0.999384,0.00006236212,0.00003518836,0.0001226649,0.0002565175,0.0001392478],"domain_scores_gemma":[0.9985731,0.00006106634,0.0001223108,0.00003785019,0.000858847,0.0003468941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007121486,0.00006179637,0.9814719,0.0000851838,0.00006607961,0.0003369295,0.0007360048,0.0002712671,0.001686412,0.0002611521,0.004604652,0.0103474],"study_design_scores_gemma":[0.00001750852,0.00005098333,0.994586,0.00006117358,0.00003445802,0.0002693553,0.00112618,0.0004577124,0.0002921344,0.00005471414,0.003033937,0.00001578352],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584556,0.003982387,0.001589405,0.00156881,0.00007453439,0.0007725254,0.01870714,0.0001651177,0.0146845],"genre_scores_gemma":[0.987417,0.002692769,0.002227368,0.0006225187,0.00001968936,0.0001227901,0.002968465,0.00001808583,0.003911379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02287576,"threshold_uncertainty_score":0.165976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06560248744996193,"score_gpt":0.288765241259937,"score_spread":0.2231627538099751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}