{"id":"W2800435336","doi":"10.1038/s41598-018-21372-3","title":"Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Elitenetzwerk Bayern; Else Kröner-Fresenius-Stiftung","keywords":"Ectopic expression; Phosphorylation; Biology; Cell biology; Histone H3; Histone; Mitochondrion; Mitochondrial biogenesis; Gene expression; Serine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000601675,0.0002347944,0.0001131916,0.0001850614,0.0001192448,0.0001550533,0.0001480245,0.0001866051,0.0009427044],"category_scores_gemma":[0.0000425544,0.00009784081,0.0001804336,0.0001114546,0.0002191403,0.0001010436,0.0001848177,0.0003015102,0.0002364663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535856,"about_ca_system_score_gemma":0.0001337539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353061,"about_ca_topic_score_gemma":0.002732051,"domain_scores_codex":[0.9999536,0.00000511262,0.000005352628,0.00001540041,0.00001094135,0.000009581557],"domain_scores_gemma":[0.9999408,0.000006690271,0.00002129999,0.000004953973,0.000004408933,0.00002190294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003987026,0.000006056183,0.0002480866,0.00001574738,0.000003084,0.000029406,0.000009358269,0.00004023704,0.9989956,0.00003813678,0.00002090544,0.0005535391],"study_design_scores_gemma":[0.00003302133,0.0001864512,0.03659628,0.00001125727,0.0000345466,0.0002924538,0.00008439313,0.002290363,0.957372,0.0001057202,0.002982464,0.00001107775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966922,0.0005162859,0.001160265,0.00003859042,0.000008939721,0.00001170467,0.0007135342,0.00004317679,0.0008153151],"genre_scores_gemma":[0.995571,0.0003820322,0.001202318,0.00003337614,0.000002379354,0.00001753112,0.0005233229,0.00002912924,0.002239092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001353061,"threshold_uncertainty_score":0.003153682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007594048510106977,"score_gpt":0.2350742108605907,"score_spread":0.2274801623504837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}