{"id":"W2800454763","doi":"10.1016/j.jid.2018.03.1469","title":"1451 Development of a psoriatic immunocompetent organotypic 3D model as a new promising preclinical tool","year":2018,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Psoriasis; Involucrin; Loricrin; Imiquimod; Immunology; STAT1; Cytokine; Medicine; Inflammation; Western blot; Cancer research; Biology; Keratinocyte; Cell culture; Interferon; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008279975,0.0006372766,0.0005096144,0.0006477424,0.0003154898,0.001053766,0.0005219419,0.0006791381,0.003517952],"category_scores_gemma":[0.0002425682,0.0002424817,0.000634311,0.000294603,0.0003167952,0.0006018712,0.0003511693,0.002123491,0.001536656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452037,"about_ca_system_score_gemma":0.0005179348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000575906,"about_ca_topic_score_gemma":0.001079039,"domain_scores_codex":[0.9994797,0.0001170158,0.00004003063,0.00006513134,0.0002114998,0.0000866905],"domain_scores_gemma":[0.9997379,0.00004754801,0.00004766451,0.00004880229,0.00005239872,0.00006563434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002266873,0.0004043008,0.0002164316,0.000202476,0.0000149949,0.0002127927,0.00004197031,0.000350704,0.9901283,0.001013323,0.0006590803,0.00652891],"study_design_scores_gemma":[0.0001253256,0.002574736,0.002679738,0.0001046631,0.0001129344,0.0009034228,0.0001175165,0.002951142,0.9597729,0.0006384766,0.02999411,0.00002515844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7466394,0.02125364,0.1777421,0.002192868,0.002837469,0.001779675,0.006262992,0.001417422,0.03987452],"genre_scores_gemma":[0.8801907,0.01132565,0.08625161,0.0007937573,0.0002208228,0.001455014,0.004692026,0.0001672143,0.01490322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003517952,"threshold_uncertainty_score":0.01176876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04593572583007566,"score_gpt":0.2904196774678397,"score_spread":0.244483951637764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}