{"id":"W2800482692","doi":"10.1093/hmg/ddy121","title":"Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero","year":2018,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Medical Research Council; National Institutes of Health; Government of Western Australia; Erasmus Universiteit Rotterdam; Edith Cowan University; ZonMw; Raine Medical Research Foundation; Erasmus Medisch Centrum; University of Bristol; Curtin University of Technology; European Commission; Australian Research Council; King's College London; National Health and Medical Research Council; Women and Infants Research Foundation; National Institute for Health and Care Research; Australian Government; QIMR Berghofer Medical Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Canadian Institutes of Health Research; Wellcome","keywords":"Biology; Digit ratio; Testosterone (patch); Genome-wide association study; Biomarker; Androgen receptor; Sex hormone-binding globulin; Genetics; Androgen; Population; Sexual dimorphism; Microsatellite; Genotype; Single-nucleotide polymorphism; Gene; Endocrinology; Hormone; Cancer; Prostate cancer; Allele; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004064277,0.0005065965,0.001003888,0.000270299,0.000111008,0.00009156281,0.000351296,0.0004914789,0.00003558867],"category_scores_gemma":[0.0005196789,0.0005221121,0.0003612763,0.0002669845,0.00009470809,0.000005911089,0.0002025569,0.0001567571,0.000005096589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001497886,"about_ca_system_score_gemma":0.0001617104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001127835,"about_ca_topic_score_gemma":0.0001815561,"domain_scores_codex":[0.9972662,0.0002590253,0.000957392,0.0008033007,0.0003546177,0.0003594039],"domain_scores_gemma":[0.997899,0.0000637878,0.0009252156,0.0005796495,0.0004649025,0.00006742348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001080858,0.02649539,0.1124068,0.03897941,0.03517041,0.0001599082,0.01690266,0.0006398288,0.6840682,0.0005333911,0.01367789,0.06988527],"study_design_scores_gemma":[0.02881425,0.02167966,0.3962831,0.003838754,0.01037827,0.0000229015,0.003405871,0.000208861,0.02476194,0.001462277,0.5000278,0.009116253],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2331589,0.7475436,0.01525364,0.00001014328,0.0002307594,0.003305488,0.000387455,0.00001720967,0.00009279509],"genre_scores_gemma":[0.5198101,0.4518704,0.002308948,0.0003688605,0.0005223604,0.001845931,0.01955177,0.0005582083,0.003163443],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6593063,"threshold_uncertainty_score":0.999723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480469617453831,"score_gpt":0.3390707527091379,"score_spread":0.2942660565345996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}