{"id":"W2800505418","doi":"10.1186/s40695-018-0037-y","title":"Prophylactic salpingo-oophorectomy &amp; surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease","year":2018,"lang":"en","type":"article","venue":"Women s Midlife Health","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Health; University of Calgary","funders":"Canadian Institutes of Health Research; Canadian Vascular Network","keywords":"Medicine; Menopause; Surgical Menopause; Endometrial cancer; Breast cancer; Coronary artery disease; Hormone replacement therapy (female-to-male); Gynecology; Internal medicine; Oophorectomy; Premature Menopause; Ovarian cancer; Cancer; Surgery; Hysterectomy; Testosterone (patch)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001668447,0.0001516368,0.0003087846,0.0002269698,0.0002500144,0.0004822101,0.0002613752,0.0003503578,0.001072231],"category_scores_gemma":[0.002747406,0.0001385703,0.0002012865,0.0003809547,0.0002421303,0.0003665226,0.0002122708,0.0004301928,0.0001308655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544317,"about_ca_system_score_gemma":0.0005756834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296211,"about_ca_topic_score_gemma":0.002793564,"domain_scores_codex":[0.9996921,0.0001227593,0.00002580578,0.00004106133,0.0000914755,0.00002668435],"domain_scores_gemma":[0.998716,0.0004000378,0.0005594139,0.00008502838,0.0001045947,0.0001348873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008467148,0.0001787409,0.959543,0.0001108386,0.00006835903,0.0001141174,0.00008221239,0.00004984199,0.0009157231,0.000118387,0.0005134361,0.03745861],"study_design_scores_gemma":[0.00006767451,0.001165258,0.9954145,0.0001053672,0.00007291515,0.0006322325,0.0001880253,0.0002269954,0.0002267222,0.0003511536,0.001541919,0.000007258363],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886536,0.006615879,0.0009845084,0.001582245,0.00007382868,0.0001281378,0.0005446464,0.00001069269,0.001406525],"genre_scores_gemma":[0.9932987,0.002871952,0.002336811,0.0006131513,0.0001031963,0.0001095111,0.000291486,0.000002595402,0.0003726472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668447,"threshold_uncertainty_score":0.008823752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04312564655681462,"score_gpt":0.3956515459957932,"score_spread":0.3525258994389786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}