{"id":"W2800533296","doi":"10.1016/j.antiviral.2018.04.009","title":"Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses","year":2018,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Respiratory viral infections research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Zanamivir; Neuraminidase; Recombinant DNA; Titer; In vitro; Mutant; Enzyme; Oseltamivir; Virus; Biology; Virulence; Chemistry; Virology; IC50; Wild type; Molecular biology; Biochemistry; Gene; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006330497,0.0006112803,0.0003358068,0.000219341,0.0002737556,0.000580076,0.0005912929,0.0005200694,0.001875299],"category_scores_gemma":[0.001097451,0.0002186536,0.0004864447,0.0002425633,0.0004223458,0.0003879215,0.0003295599,0.0006969114,0.0008010879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006711576,"about_ca_system_score_gemma":0.0005101611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003117967,"about_ca_topic_score_gemma":0.002701418,"domain_scores_codex":[0.9991831,0.0002693375,0.0001586207,0.00009188135,0.0001710598,0.0001259506],"domain_scores_gemma":[0.9993927,0.0002433653,0.0001265487,0.00007306498,0.0000845098,0.00007986156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001175267,0.0003065001,0.001763077,0.00006110594,0.00005984153,0.0002915046,0.00007173344,0.001244553,0.9921078,0.0002455954,0.000140212,0.002532847],"study_design_scores_gemma":[0.00003909087,0.0007814301,0.003705018,0.00001435086,0.00006721832,0.000406083,0.00009223034,0.002476391,0.991142,0.0000692808,0.001187719,0.00001911816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984939,0.0002598106,0.0003005753,0.0000450484,0.00003378007,0.00001122724,0.0002298715,0.00001090918,0.0006148755],"genre_scores_gemma":[0.998067,0.0001325543,0.0005961016,0.00003827256,0.000007451376,0.000007859497,0.0004604696,0.00002422565,0.0006661045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003117967,"threshold_uncertainty_score":0.006273568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2609823295260614,"score_gpt":0.4754012148655624,"score_spread":0.214418885339501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}