{"id":"W2800533296","doi":"10.1016/j.antiviral.2018.04.009","title":"Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses","year":2018,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Respiratory viral infections research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"Zanamivir; Neuraminidase; Recombinant DNA; Titer; In vitro; Mutant; Enzyme; Oseltamivir; Virus; Biology; Virulence; Chemistry; Virology; IC50; Wild type; Molecular biology; Biochemistry; Gene; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001365127,0.0001538518,0.0003922723,0.001003381,0.000164144,0.00003762066,0.0001390284,0.0001025553,0.00001555493],"category_scores_gemma":[0.001930207,0.0001092233,0.00006510123,0.001072023,0.002739802,0.0002784351,0.0001850678,0.0005525078,0.00003708182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247559,"about_ca_system_score_gemma":0.0004518044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003253992,"about_ca_topic_score_gemma":0.0001371115,"domain_scores_codex":[0.9977643,0.0003285912,0.0003868281,0.0003766523,0.0006458312,0.0004977293],"domain_scores_gemma":[0.9985228,0.000321335,0.00006064695,0.0004413815,0.0005367547,0.0001170896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001861636,0.0005450581,0.1062207,0.0002119724,0.00004098282,0.00004259077,0.0002793068,4.685378e-7,0.8798782,0.0002664192,0.0001367284,0.01051592],"study_design_scores_gemma":[0.0009398523,0.004873837,0.3633864,0.0003493743,0.00001010309,0.00001936145,0.0001028143,0.0004040276,0.6296736,0.00009170792,0.0000591144,0.00008983873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971978,0.0003969221,0.000002918363,0.0001415532,0.00003687673,0.0006486123,0.00001609045,0.00001296633,0.001546239],"genre_scores_gemma":[0.9992689,0.0002792264,0.00002583487,0.00001863164,0.00003858806,0.00003044674,0.000002682037,0.00001836151,0.0003172693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2571657,"threshold_uncertainty_score":0.9999742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2609823295260614,"score_gpt":0.4754012148655624,"score_spread":0.214418885339501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}