{"id":"W2800535233","doi":"10.1101/322610","title":"Glucocorticoid-mediated Aβ and SCG10 upregulation evoke microtubule dysfunction and memory deficits","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Research Foundation of Korea; National Research Foundation","keywords":"Downregulation and upregulation; Mitochondrion; Autophagy; Cell biology; Microtubule; Glucocorticoid receptor; Biology; Glucocorticoid; Chemistry; Apoptosis; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007921815,0.0003725058,0.0002712428,0.0002648177,0.0001470852,0.0002051029,0.0001259309,0.0003717694,0.001482228],"category_scores_gemma":[0.0000580926,0.00009472565,0.000334105,0.0001557101,0.0002471879,0.0001432556,0.0001695109,0.0005259386,0.0002886637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256394,"about_ca_system_score_gemma":0.0001697168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244422,"about_ca_topic_score_gemma":0.002117627,"domain_scores_codex":[0.9998945,0.00001248082,0.00000877273,0.00002299667,0.00002636239,0.00003479739],"domain_scores_gemma":[0.999946,0.000003422514,0.00001479659,0.000006399234,0.000007956005,0.00002144437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003409168,0.00002703813,0.0003084135,0.00004037789,0.00001078104,0.0001308725,0.00001495911,0.00001907435,0.9980558,0.00003154939,0.00005986892,0.0009603701],"study_design_scores_gemma":[0.00003437683,0.0005779314,0.01544029,0.00001176205,0.00003291529,0.0004695774,0.00008230341,0.0002011472,0.980935,0.00009346105,0.002114335,0.000006902051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994835,0.002470725,0.0007058766,0.0001401288,0.00006728218,0.00002186465,0.0005960485,0.00005554871,0.001107556],"genre_scores_gemma":[0.9962627,0.000916815,0.0005882828,0.00007682311,0.00001419264,0.00002280786,0.0002944032,0.000008652769,0.001815259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482228,"threshold_uncertainty_score":0.00495851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154213232228345,"score_gpt":0.2443008938653991,"score_spread":0.2288795706425646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}